Design and synthesis of benzene homologues tethered with 1, 2, 4-triazole and 1, 3, 4-thiadiazole motifs revealing dual MCF-7/HepG2 cytotoxic activity with prominent …
M Alsehli, A Aljuhani, SK Ihmaid… - International Journal of …, 2022 - mdpi.com
In this study, an efficient multistep synthesis of novel aromatic tricyclic hybrids incorporating
different biological active moieties, such as 1, 3, 4-thiadiazole and 1, 2, 4-triazole, was …
different biological active moieties, such as 1, 3, 4-thiadiazole and 1, 2, 4-triazole, was …
Novel 1, 2, 4‐triazole derivatives: Design, synthesis, anticancer evaluation, molecular docking, and pharmacokinetic profiling studies
A Turky, FF Sherbiny, AH Bayoumi… - Archiv der …, 2020 - Wiley Online Library
Abstract Three novel series of 1, 2, 4‐triazole derivatives were designed and synthesized as
potential adenosine A2B receptor antagonists. The design of the new compounds depended …
potential adenosine A2B receptor antagonists. The design of the new compounds depended …
An in silico investigation of 1, 2, 4-triazole derivatives as potential antioxidant agents using molecular docking, MD simulations, MM-PBSA free energy calculations and …
YO Karpun, SO Fedotov, AV Khilkovets, YV Karpenko… - 2023 - dspace.zsmu.edu.ua
In this study, we've performed computable studies of previously synthesized 1, 2, 4-triazole
derivatives by virtual screening due to antioxidant activity. Six enzymes responsible for …
derivatives by virtual screening due to antioxidant activity. Six enzymes responsible for …
Synthesis, crystal structure, DFT and Hirshfeld surface analysis of 4-fluoro-N-(1, 3-dioxoisoindolin-2-yl) benzamide
R Elancheran, B Karthikeyan, S Srinivasan… - European Journal of …, 2023 - eurjchem.com
Abstract The 4-fluoro-N-(1, 3-dioxoisoindolin-2-yl) benzamide was synthesized by the
reaction of 4-fluorobenzohydrazide with phthalic anhydride in acetic acid. The compound …
reaction of 4-fluorobenzohydrazide with phthalic anhydride in acetic acid. The compound …
Design, Synthesis and Biological Activity Evaluation of S-Substituted 1H-5-Mercapto-1,2,4-Triazole Derivatives as Antiproliferative Agents in Colorectal Cancer
Colon cancer is a widespread pathology with complex biochemical etiology based on a
significant number of intracellular signaling pathways that play important roles in …
significant number of intracellular signaling pathways that play important roles in …
Secosteroid thiosemicarbazides and secosteroid–1, 2, 4-triazoles as antiproliferative agents targeting breast cancer cells: Synthesis and biological evaluation
AI Ilovaisky, AM Scherbakov, EI Chernoburova… - The Journal of Steroid …, 2023 - Elsevier
A convenient and selective approach to 13, 17-secoestra-1, 3, 5 (10)-trien-17-oic acid [N'-
arylcarbothioamido] hydrazides and hybrid molecules containing secosteroid and 1, 2, 4 …
arylcarbothioamido] hydrazides and hybrid molecules containing secosteroid and 1, 2, 4 …
Synthesis, crystal structure and evaluation of the cytotoxic, antimicrobial activity of some S-and N-derivatives of 5-phenyl-1, 2, 4-triazole-2, 4-dihydro-3-thione
In this work, we report the synthesis of several S-and N-derivatives of 5-phenyl-1, 2, 4-
triazole-2, 4-dihydro-3-thione (3-6). Methods for the preparation of these compounds were …
triazole-2, 4-dihydro-3-thione (3-6). Methods for the preparation of these compounds were …
Synthesis and biological activities of cyclanone O-(2-(3-aryl-4- amino-4H-1,2,4-triazol-3-yl)thio)acetyl)oxime derivatives
M Chen, L Chen, X Zhu, X Wang, Q Li… - … , Sulfur, and Silicon …, 2017 - Taylor & Francis
ABSTRACT Twelve cyclanone O-(2-(3-aryl-4-amino-4 H-1, 2, 4-triazol-3-yl) thio) acetyl)
oxime derivatives were synthesized and their structures were confirmed by spectroscopy (IR …
oxime derivatives were synthesized and their structures were confirmed by spectroscopy (IR …
Synthesis and cytotoxicity evaluation of N-(5-Mercapto-4H-1, 2, 4-triazol-3-yl)-2-phenylacetamide derivatives as apoptosis inducers with potential anticancer effects
A Mohammadi-Farani, HSZ Mousavi… - Journal of Reports in …, 2020 - journals.lww.com
Background: Discovery of new anticancer drugs is one of the urgent issues in the medicinal
chemistry researches. Incidence of severe side effects and acquired resistance to the current …
chemistry researches. Incidence of severe side effects and acquired resistance to the current …
Synthesis, structural characterization and cancer cell cytotoxic activity of Vadimezan hydrazones
SJ Zhang, F Xu, QF Ge, HB Li, WX Hu - Pharmaceutical Chemistry Journal, 2016 - Springer
New vadimezan hydrazones were synthesized as E/Z isomers and characterized by IR, 1H
NMR, MS, and HRMS techniques; the ratio of isomers was analyzed by NOESY spectra. All …
NMR, MS, and HRMS techniques; the ratio of isomers was analyzed by NOESY spectra. All …