Low-dose ionizing radiation as a hormetin: experimental observations and therapeutic perspective for age-related disorders

A Vaiserman, JM Cuttler, Y Socol - Biogerontology, 2021 - Springer
Hormesis is any kind of biphasic dose-response when low doses of some agents are
beneficial while higher doses are detrimental. Radiation hormesis is the most thoroughly …

Autophagy-lysosomal pathway as potential therapeutic target in Parkinson's disease

SR Bonam, C Tranchant, S Muller - Cells, 2021 - mdpi.com
Cellular quality control systems have gained much attention in recent decades. Among
these, autophagy is a natural self-preservation mechanism that continuously eliminates toxic …

Fisetin rescues the mice brains against D-galactose-induced oxidative stress, neuroinflammation and memory impairment

S Ahmad, A Khan, W Ali, MH Jo, J Park… - Frontiers in …, 2021 - frontiersin.org
Herein, we have evaluated the protective potentials of Fisetin against d-galactose-induced
oxidative stress, neuroinflammation, and memory impairment in mice. d-galactose (D-gal) …

Low-dose ionizing radiation modulates microglia phenotypes in the models of Alzheimer's disease

S Kim, H Chung, H Ngoc Mai, Y Nam, SJ Shin… - International journal of …, 2020 - mdpi.com
Alzheimer's disease (AD) is the most common type of dementia. AD involves major
pathologies such as amyloid-β (Aβ) plaques and neurofibrillary tangles in the brain. During …

Low-dose radiation therapy (LDRT) for COVID-19: Benefits or risks?

PG Prasanna, GE Woloschak, AL DiCarlo… - Radiation …, 2020 - meridian.allenpress.com
The limited impact of treatments for COVID-19 has stimulated several phase 1 clinical trials
of whole-lung low-dose radiation therapy (LDRT; 0.3–1.5 Gy) that are now progressing to …

Therapeutic effects of non-saponin fraction with rich polysaccharide from Korean red ginseng on aging and Alzheimer's disease

SJ Shin, Y Nam, YH Park, MJ Kim, E Lee… - Free Radical Biology …, 2021 - Elsevier
Biological aging provokes morbidity and several functional declines, causing older adults
more susceptible to a variety of diseases than younger adults. In particular, aging is a major …

Low doses of ionizing radiation as a treatment for Alzheimer's disease: a pilot study

JM Cuttler, E Abdellah, Y Goldberg… - Journal of …, 2021 - content.iospress.com
Background: In 2015, a patient in hospice with Alzheimer's disease (AD) was treated with
ionizing radiation to her brain using repeated CT scans. Improvement in cognition, speech …

Therapeutic potential of low dose ionizing radiation against cancer, dementia, and diabetes: evidences from epidemiological, clinical, and preclinical studies

JG Paithankar, SC Gupta, A Sharma - Molecular biology reports, 2023 - Springer
The growing use of ionizing radiation (IR)-based diagnostic and treatment methods has
been linked to increasing chronic diseases among patients and healthcare professionals …

Genome-wide study reveals novel roles for formin-2 in axon regeneration as a microtubule dynamics regulator and therapeutic target for nerve repair

NPB Au, T Wu, X Chen, F Gao, YTY Li, WY Tam, KN Yu… - Neuron, 2023 - cell.com
Peripheral nerves regenerate successfully; however, clinical outcome after injury is poor. We
demonstrated that low-dose ionizing radiation (LDIR) promoted axon regeneration and …

Low-dose radiation therapy (LDRT) against cancer and inflammatory or degenerative diseases: Three parallel stories with a common molecular mechanism involving …

E Le Reun, N Foray - Cancers, 2023 - mdpi.com
Simple Summary We reviewed the medical applications of low-dose radiation therapy
(LDRT) in cancer and inflammatory and degenerative diseases by proposing a unified …