[HTML][HTML] Antioxidant properties of flavonoid metal complexes and their potential inclusion in the development of novel strategies for the treatment against …

E Rodríguez-Arce, M Saldías - Biomedicine & Pharmacotherapy, 2021 - Elsevier
The increased oxidative stress in the acceleration of the aging process and development of
the neuronal disorder are the common feature detected in neurodegenerative illness, such …

In vivo imaging with genetically encoded redox biosensors

AI Kostyuk, AS Panova, AD Kokova, DA Kotova… - International journal of …, 2020 - mdpi.com
Redox reactions are of high fundamental and practical interest since they are involved in
both normal physiology and the pathogenesis of various diseases. However, this area of …

Facing diseases caused by trypanosomatid parasites: rational design of Pd and Pt complexes with bioactive ligands

D Gambino, L Otero - Frontiers in Chemistry, 2022 - frontiersin.org
Human African Trypanosomiasis (HAT), Chagas disease or American Trypanosomiasis
(CD), and leishmaniases are protozoan infections produced by trypanosomatid parasites …

Drug-like molecules with anti-trypanothione synthetase activity identified by high throughput screening

D Benítez, J Franco, F Sardi, A Leyva… - Journal of enzyme …, 2022 - Taylor & Francis
Trypanothione synthetase (TryS) catalyses the synthesis of N 1, N8-bis (glutathionyl)
spermidine (trypanothione), which is the main low molecular mass thiol supporting several …

New multifunctional Ru (II) organometallic compounds show activity against Trypanosoma brucei and Leishmania infantum

F Rivas, C Del Mármol, G Scalese, L Pérez-Díaz… - Journal of Inorganic …, 2022 - Elsevier
Human African trypanosomiasis (sleeping sickness) and leishmaniasis are prevalent
zoonotic diseases caused by genomically related trypanosomatid protozoan parasites …

Microwave-Assisted Synthesis of (Piperidin-1-yl) quinolin-3-yl) methylene) hydrazinecarbothioamides as Potent Inhibitors of Cholinesterases: A Biochemical and In …

R Munir, M Zia-ur-Rehman, S Murtaza, S Zaib, N Javid… - Molecules, 2021 - mdpi.com
Alzheimer's disease (AD), a progressive neurodegenerative disorder, characterized by
central cognitive dysfunction, memory loss, and intellectual decline poses a major public …

Organometallics in Medicinal Chemistry: Antiparasitic Agents

D Gambino - Journal of the Brazilian Chemical Society, 2024 - SciELO Brasil
Neglected tropical diseases (NTDs) encompass a diverse group of 20 medical conditions
triggered by various pathogens, including viruses, bacteria, protozoa, and parasitic worms …

New Pd–Fe ferrocenyl antiparasitic compounds with bioactive 8-hydroxyquinoline ligands: a comparative study with their Pt–Fe analogues

F Rivas, A Medeiros, C Quiroga, D Benitez… - Dalton …, 2021 - pubs.rsc.org
In the search for a more effective chemotherapy for the treatment of Human African
Trypanosomiasis, a disease caused by the parasite Trypanosoma brucei, the development …

Pt-Fe ferrocenyl compounds with hydroxyquinoline ligands show selective cytotoxicity on highly proliferative cells

F Rivas, A Medeiros, M Comini, L Suescun… - Journal of inorganic …, 2019 - Elsevier
Searching for a more effective chemotherapy for the treatment of Human African
trypanosomiasis, the disease caused by the parasite Trypanosoma brucei, and cancer, in …

Multifunctional Organometallic Compounds Active against Infective Trypanosomes: Ru (II) Ferrocenyl Derivatives with Two Different Bioactive Ligands

F Rivas, C Del Mármol, G Scalese… - Inorganic …, 2024 - ACS Publications
Human African trypanosomiasis (HAT, sleeping sickness) and American trypanosomiasis
(Chagas disease) are endemic zoonotic diseases caused by genomically related …