Small intestinal bacterial overgrowth (SIBO) is a common, yet underrecognized, problem. Its
prevalence is unknown because SIBO requires diagnostic testing. Although abdominal …

Abnormalities in the gastrointestinal (GI) tract of Parkinson's disease (PD) sufferers were first
reported over 200 years ago; however, the extent and role of GI dysfunction in PD disease …

Abstract Introduction The Comprehensive in vitro Proarrhythmia Assay (CiPA) initiative
seeks an in vitro test to accurately predict clinical Torsades de Pointes (TdP). We developed …

Drug safety initiatives have endorsed human iPSC-derived cardiomyocytes (hiPSC-CMs) as
an in vitro model for predicting drug-induced cardiac arrhythmia. However, the extent to …

Background Proarrhythmia assessment is one of the major concerns for regulatory bodies
and pharmaceutical industry. ICH guidelines recommending preclinical tests have been …

Purpose Sudden cardiac death (SD) and ventricular arrhythmias (VAs) caused by
medications have arisen as an important public health concern in recent years. The validity …

Systemic sclerosis is an autoimmune disease characterized by vasculopathy, progressive
fibrosis of the skin, and internal organ dysfunction. Gastrointestinal (GI) disease is the most …

Gastroparesis is a chronic motility disorder of the stomach that involves delayed emptying of
solids and liquids, without evidence of mechanical obstruction. Although no cause can be …

Constipation, a condition characterized by heterogeneous symptoms, is common in Western
society. It is associated with reduced physical health, mental health, and social functioning …

Background Due to scarcity of scientific literature on pediatric gastroparesis, there is a need
to summarize current evidence and identify areas requiring further research. The aim of this …