Abnormalities in the gastrointestinal (GI) tract of Parkinson's disease (PD) sufferers were first reported over 200 years ago; however, the extent and role of GI dysfunction in PD disease …
GT Dempsey, KW Chaudhary, N Atwater… - … of pharmacological and …, 2016 - Elsevier
Abstract Introduction The Comprehensive in vitro Proarrhythmia Assay (CiPA) initiative seeks an in vitro test to accurately predict clinical Torsades de Pointes (TdP). We developed …
Drug safety initiatives have endorsed human iPSC-derived cardiomyocytes (hiPSC-CMs) as an in vitro model for predicting drug-induced cardiac arrhythmia. However, the extent to …
B Wiśniowska, Z Tylutki, G Wyszogrodzka… - BMC Pharmacology and …, 2016 - Springer
Background Proarrhythmia assessment is one of the major concerns for regulatory bodies and pharmaceutical industry. ICH guidelines recommending preclinical tests have been …
S Hennessy, CE Leonard, CP Freeman… - … and drug safety, 2010 - Wiley Online Library
Purpose Sudden cardiac death (SD) and ventricular arrhythmias (VAs) caused by medications have arisen as an important public health concern in recent years. The validity …
JB Miller, N Gandhi, J Clarke… - JCR: Journal of Clinical …, 2018 - journals.lww.com
Systemic sclerosis is an autoimmune disease characterized by vasculopathy, progressive fibrosis of the skin, and internal organ dysfunction. Gastrointestinal (GI) disease is the most …
DM Tang, FK Friedenberg - Disease-a-Month, 2011 - Elsevier
Gastroparesis is a chronic motility disorder of the stomach that involves delayed emptying of solids and liquids, without evidence of mechanical obstruction. Although no cause can be …
DO Prichard, AE Bharucha - F1000Research, 2018 - ncbi.nlm.nih.gov
Constipation, a condition characterized by heterogeneous symptoms, is common in Western society. It is associated with reduced physical health, mental health, and social functioning …
K Kovacic, W Elfar, JM Rosen, D Yacob… - …, 2020 - Wiley Online Library
Background Due to scarcity of scientific literature on pediatric gastroparesis, there is a need to summarize current evidence and identify areas requiring further research. The aim of this …