Simple Summary Breast cancer remains the most commonly diagnosed cancer and the
leading cause of cancer death among females worldwide. It is a highly heterogeneous …

A growing amount of evidence indicates that the neuronally expressed developmentally
downregulated 4 (NEDD4, also known as NEDD4-1) E3 ligase plays a critical role in a …

Over 50% of all patients with cancer are treated with radiotherapy. However, radiotherapy is
often insufficient as a monotherapy and requires a nontoxic radiosensitizer. Squalene …

With the rapidly increasing incidence of bladder cancer in China and worldwide, great efforts
have been made to understand the detailed mechanism of bladder cancer tumorigenesis …

The neuronally expressed developmentally downregulated 4 (NEDD4) gene encodes a
ubiquitin ligase that targets the epithelial sodium channel for degradation and has been …

Abstract Background Prohibitin 2 (PHB2) exhibits opposite functions of promoting or
inhibiting tumour across various cancer types. In this study, we aim to investigate its …

ABSTRACT NEDD4 is an E3 ubiquitin ligase that recognizes substrates through protein–
protein interactions and is involved in cancer development. This study aimed to elucidate the …

Cancer is a deadly disease worldwide, with an anticipated 19.3 million new cases and 10.0
million deaths occurring in 2020 according to GLOBOCAN 2020. It is well established that …

Luminal A breast cancer, constituting 70% of breast cancer cases, presents a challenge due
to the development of resistance and recurrence caused by breast cancer stem cells …

Abstract PP2A B55α, encoded by PPP2R2A, acts as a regulatory subunit of the
serine/threonine phosphatase PP2A. Despite a frequent loss of heterozygosity of PPP2R2A …