[HTML][HTML] Neuroprotection in glaucoma: mechanisms beyond intraocular pressure lowering
Glaucoma is a common, complex, multifactorial neurodegenerative disease characterized
by progressive dysfunction and then loss of retinal ganglion cells, the output neurons of the …
by progressive dysfunction and then loss of retinal ganglion cells, the output neurons of the …
[HTML][HTML] Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules
The NADase SARM1 (sterile alpha and TIR motif containing 1) is a key executioner of axon
degeneration and a therapeutic target for several neurodegenerative conditions. We show …
degeneration and a therapeutic target for several neurodegenerative conditions. We show …
Sarm1-dependent axon degeneration: Nucleotide signaling, neurodegenerative disorders, toxicity, and therapeutic opportunities
Axons are an essential component of the nervous system, and axon degeneration is an
early feature of many neurodegenerative disorders. The NAD+ metabolome plays an …
early feature of many neurodegenerative disorders. The NAD+ metabolome plays an …
Selective inhibitors of SARM1 targeting an allosteric cysteine in the autoregulatory ARM domain
HC Feldman, E Merlini, C Guijas… - Proceedings of the …, 2022 - National Acad Sciences
The nicotinamide adenine dinucleotide hydrolase (NADase) sterile alpha toll/interleukin
receptor motif containing-1 (SARM1) acts as a central executioner of programmed axon …
receptor motif containing-1 (SARM1) acts as a central executioner of programmed axon …
SARM1 is a multi-functional NAD (P) ase with prominent base exchange activity, all regulated bymultiple physiologically relevant NAD metabolites
Summary SARM1 is an NAD (P) glycohydrolase and TLR adapter with an essential,
prodegenerative role in programmed axon death (Wallerian degeneration). Like other NAD …
prodegenerative role in programmed axon death (Wallerian degeneration). Like other NAD …
Enrichment of SARM1 alleles encoding variants with constitutively hyperactive NADase in patients with ALS and other motor nerve disorders
SARM1, a protein with critical NADase activity, is a central executioner in a conserved
programme of axon degeneration. We report seven rare missense or in-frame microdeletion …
programme of axon degeneration. We report seven rare missense or in-frame microdeletion …
Neurotoxin-mediated potent activation of the axon degeneration regulator SARM1
Axon loss underlies symptom onset and progression in many neurodegenerative disorders.
Axon degeneration in injury and disease is promoted by activation of the NAD-consuming …
Axon degeneration in injury and disease is promoted by activation of the NAD-consuming …
Multifaceted roles of SARM1 in axon degeneration and signaling
TJ Waller, CA Collins - Frontiers in Cellular Neuroscience, 2022 - frontiersin.org
Axons are considered to be particularly vulnerable components of the nervous system;
impairments to a neuron's axon leads to an effective silencing of a neuron's ability to …
impairments to a neuron's axon leads to an effective silencing of a neuron's ability to …
Augustus Waller's foresight realized: SARM1 in peripheral neuropathies
S Geisler - Current Opinion in Neurobiology, 2024 - Elsevier
Peripheral neuropathy is a common neurodegenerative condition characterized by
numbness, tingling, pain, and weakness that frequently starts in the distal limbs. Arising from …
numbness, tingling, pain, and weakness that frequently starts in the distal limbs. Arising from …
Nicotinic acid mononucleotide is an allosteric SARM1 inhibitor promoting axonal protection
SARM1 is an inducible NAD+ hydrolase that is the central executioner of pathological axon
loss. Recently, we elucidated the molecular mechanism of SARM1 activation, demonstrating …
loss. Recently, we elucidated the molecular mechanism of SARM1 activation, demonstrating …