This review summarizes our current understanding of translation in prokaryotes, focusing on
the mechanistic and structural aspects of each phase of translation: initiation, elongation …

This work summarizes our current understanding of the elongation and termination/recycling
phases of eukaryotic protein synthesis. We focus here on recent advances in the field. In …

The high-resolution structures of ribosomal subunits published in 2000 have revolutionized
the field of protein translation. They facilitated the determination and interpretation of …

We describe two structures of the intact bacterial ribosome from Escherichia coli determined
to a resolution of 3.5 angstroms by x-ray crystallography. These structures provide a detailed …

During protein synthesis, the ribosome controls the movement of tRNA and mRNA by means
of large-scale structural rearrangements. We describe structures of the intact bacterial …

After termination, eukaryotic 80S ribosomes remain associated with mRNA, P-site
deacylated tRNA, and release factor eRF1 and must be recycled by dissociating these …

Ribosomes, which are central to protein synthesis and convert transcribed mRNAs into
polypeptide chains, have been the focus of structural and biochemical studies for more than …

Aminoglycosides are widely used antibiotics that cause messenger RNA decoding errors,
block mRNA and transfer RNA translocation, and inhibit ribosome recycling. Ribosome …

Ribosome biogenesis requires auxiliary factors to promote folding and assembly of
ribosomal proteins and RNA. Particularly, maturation of the peptidyl transferase center (PTC) …

The rapid kinetics of biological processes and associated short-lived conformational
changes pose a significant challenge in attempts to structurally visualize biomolecules …