Amyotrophic lateral sclerosis (ALS) is a heterogeneous group of neurological conditions
which have in common the progressive degeneration of upper and lower motor neurons …

The efficient study of human disease requires the proper tools, one of the most crucial of
which is an accurate animal model that faithfully recapitulates the human condition. The …

Frontotemporal dementia (FTD) and Amyotrophic Lateral Sclerosis (ALS) are two
neurodegenerative diseases with clinical, genetic and pathological overlap. As such, they …

Developing effective treatments for neurodegenerative diseases such as amyotrophic lateral
sclerosis (ALS) requires understanding of the underlying pathomechanisms that contribute …

Mutations in the 43 kDa transactive-response (TAR)-DNA-binding protein (TARDBP) are
associated with 2–5% of familial Amyotrophic Lateral Sclerosis (ALS) cases. TAR DNA …

Background Aggregates of TAR DNA-binding protein of 43 kDa (TDP-43) represent the
pathological hallmark of most amyotrophic lateral sclerosis (ALS) and of nearly 50% of …

D-amino acid oxidase (DAO) maintains the intracellular d-serine level which modulates the
activity of the N-methyl-d-aspartate receptor and its dysfunction has been linked to several …

Background More than 30 causative genes have been identified in familial and sporadic
amyotrophic lateral sclerosis (ALS). The next‐generation sequencing (NGS) is a powerful …

Background Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, as
currently available medications such as riluzole and edaravone aim to slow disease …

Rare missense variants play a crucial role in amyotrophic lateral sclerosis (ALS)
pathophysiology. We report rare/novel missense variants from 154 Indian ALS patients …