The innate host response in caries and periodontitis

J Meyle, H Dommisch, S Groeger… - Journal of clinical …, 2017 - Wiley Online Library
Introduction Innate immunity rapidly defends the host against infectious insults. These
reactions are of limited specificity and exhaust without providing long‐term protection …

Membrane vesicles from periodontal pathogens and their potential roles in periodontal disease and systemic illnesses

L Ma, Z Cao - Journal of Periodontal Research, 2021 - Wiley Online Library
Periodontium is an ordered ecological system where a dynamic equilibrium exists between
oral microorganisms and the host defense system, and periodontal disease occurs …

Microbiota and metatranscriptome changes accompanying the onset of gingivitis

EM Nowicki, R Shroff, JA Singleton, DE Renaud… - MBio, 2018 - Am Soc Microbiol
Over half of adults experience gingivitis, a mild yet treatable form of periodontal disease
caused by the overgrowth of oral microbes. Left untreated, gingivitis can progress to a more …

Odontogenic infection by Porphyromonas gingivalis exacerbates fibrosis in NASH via hepatic stellate cell activation

A Nagasaki, S Sakamoto, C Chea, E Ishida… - Scientific reports, 2020 - nature.com
Odontogenic infection of Porphyromonas gingivalis (Pg.), a major periodontal pathogen,
exacerbates pathological progression of non-alcoholic steatohepatitis (NASH). In this study …

Caffeic acid phenethyl ester attenuates lipopolysaccharide-stimulated proinflammatory responses in human gingival fibroblasts via NF-κB and PI3K/Akt signaling …

L Li, W Sun, T Wu, R Lu, B Shi - European Journal of Pharmacology, 2017 - Elsevier
Periodontal diseases often begin with chronic gingival inflammation, which causes the
destruction of periodontal tissues. Inflammatory immune responses from host cells to …

Antibacterial effects of Lactobacillus and bacteriocin PLNC8 αβ on the periodontal pathogen Porphyromonas gingivalis

H Khalaf, SS Nakka, C Sandén, A Svärd, K Hultenby… - BMC microbiology, 2016 - Springer
Background The complications in healthcare systems associated with antibiotic-resistant
microorganisms have resulted in an intense search for new effective antimicrobials …

Protein-Functionalized Gold Nanoparticles as Refractometric Nanoplasmonic Sensors for the Detection of Proteolytic Activity of Porphyromonas gingivalis

A Svärd, J Neilands, E Palm… - ACS Applied Nano …, 2020 - ACS Publications
Periodontitis is an inflammatory oral disease that affects a large part of the adult population,
causing significant costs and suffering. The key pathogen, Porphyromonas gingivalis …

Antimicrobial and anti-inflammatory activity of Cystatin C on human gingival fibroblast incubated with Porphyromonas gingivalis

BE Blancas-Luciano, I Becker-Fauser… - PeerJ, 2022 - peerj.com
Background Periodontal disease is considered one of the most prevalent chronic infectious
diseases, often leading to the disruption of tooth-supporting tissues, including alveolar bone …

Chlorogenic Acid as a Positive Regulator in LPS‐PG‐Induced Inflammation via TLR4/MyD88‐Mediated NF‐κB and PI3K/MAPK Signaling Cascades in Human …

CM Park, HS Yoon - Mediators of Inflammation, 2022 - Wiley Online Library
Gingival inflammation is one of the main causes that can be related to various periodontal
diseases. Human gingival fibroblast (HGF) is the major constituent in periodontal connective …

Quantum curcumin mediated inhibition of gingipains and mixed-biofilm of Porphyromonas gingivalis causing chronic periodontitis

AK Singh, S Yadav, K Sharma, Z Firdaus, P Aditi… - RSC …, 2018 - pubs.rsc.org
Periodontitis is a biofilm-associated irreversible inflammation of the periodontal tissues.
Reports suggest the role of Porphyromonas gingivalis specific Arg-and Lys-specific …