Wilms tumour (WT) is a childhood embryonal tumour that is paradigmatic of the intersection
between disrupted organogenesis and tumorigenesis. Many WT genes play a critical (non …

MicroRNAs (miRNAs) are critical regulators of gene expression. Amplification and
overexpression of individual'oncomiRs' or genetic loss of tumour suppressor miRNAs are …

Among all tumor suppressor microRNAs, reduced let-7 expression occurs most frequently in
cancer and typically correlates with poor prognosis. Activation of either LIN28A or LIN28B …

We performed genome-wide sequencing and analyzed mRNA and miRNA expression, DNA
copy number, and DNA methylation in 117 Wilms tumors, followed by targeted sequencing …

Malignant neoplasms are consistently among the top four leading causes of death in all age
groups in the United States, despite a concerted effort toward developing novel therapeutic …

Wilms tumour is the most common renal malignancy of childhood. The disease is curable in
the majority of cases, albeit at considerable cost in terms of late treatment-related effects in …

Enhanced and deregulated expression of N-MYC, a member of the MYC family of
transcription factors, drives the development of multiple tumors, including tumors of the …

RNA-binding proteins (RBPs) play a critical role in the regulation of various RNA processes,
including splicing, cleavage and polyadenylation, transport, translation and degradation of …

Blastemal histology in chemotherapy-treated pediatric Wilms tumors (nephroblastoma) is
associated with adverse prognosis. To uncover the underlying tumor biology and find …

We report the most common single-nucleotide substitution/deletion mutations in favorable
histology Wilms tumors (FHWTs) to occur within SIX1/2 (7% of 534 tumors) and microRNA …