Resistance to therapeutic treatment and metastatic progression jointly determine a fatal
outcome of cancer. Cancer metastasis and therapeutic resistance are traditionally studied as …

Over the last several decades, it has become clear that epigenetic abnormalities may be one
of the hallmarks of cancer. Posttranslational modifications of histones, for example, may play …

Histone posttranslational modifications represent a versatile set of epigenetic marks
involved not only in dynamic cellular processes, such as transcription and DNA repair, but …

Epigenetic enzymes are often dysregulated in human tumors through mutation, altered
expression, or inappropriate recruitment to certain loci. The identification of these enzymes …

Reversible acetylation of histone and non-histone proteins is one of the most abundant post-
translational modifications in eukaryotic cells. Protein acetylation and deacetylation are …

Cancer is a complex disease resulting from the genetic and epigenetic disruption of normal
cells. The mechanistic understanding of the pathways involved in tumor transformation has …

Head and neck squamous carcinoma (HNSCC) is the sixth most prevalent cancer and one
of the most aggressive malignancies worldwide. Despite continuous efforts to identify …

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with limited
therapeutic options, and there is a huge unmet need for new therapies. A growing body of …

HDACs (histone deacetylases) are a group of enzymes that deacetylate histones as well as
non-histone proteins. They are known as modulators of gene transcription and are …

Abstract Background Tyrosine kinase inhibitors (TKIs) such as sunitinib are multitarget
antiangiogenic agents in clear cell renal cell carcinoma (ccRCC). They are widely used in …