Poly-adenosine diphosphate-ribose polymerases (PARPs) promote ADP-ribosylation, a
highly conserved, fundamental posttranslational modification (PTM). PARP catalytic …

CD 4+ T‐helper cells regulate immunity and inflammation through the acquisition of
potential to secrete specific cytokines. The acquisition of cytokine‐secreting potential, in a …

Despite the global impact of macrophage activation in vascular disease, the underlying
mechanisms remain obscure. Here we show, with global proteomic analysis of macrophage …

Resistance mechanisms to immune checkpoint blockade therapy (ICBT) limit its response
duration and magnitude. Paradoxically, Interferon γ (IFNγ), a key cytokine for cellular …

Abstract Poly (ADP-ribose) polymerases (PARPs) are NAD+ dependent enzymes that were
identified as DNA repair proteins, however, today it seems clear that PARPs are responsible …

Protein ADP-ribosylation is an ancient posttranslational modification with high biochemical
complexity. It alters the function of modified proteins or provides a scaffold for the recruitment …

ADP‐ribosylation is the addition of one or more (up to some hundreds) ADP‐ribose moieties
to acceptor proteins. There are two major families of enzymes that catalyse this reaction …

ADP-ribosylation of proteins was first described in the early 1960's, and today the function
and regulation of poly (ADP-ribosyl) ation (PARylation) is partially understood. By contrast …

PARP14 has been implicated by genetic knockout studies to promote protumor macrophage
polarization and suppress the antitumor inflammatory response due to its role in modulating …

ADP-ribosylation (ADPr) is a reversible post-translational modification of proteins, which
controls major cellular and biological processes, including DNA damage repair, cell …