The administration of drugs to the central nervous system (CNS) is primarily controlled by
the blood-brain barrier (BBB), a structure that prevents the passage of foreign compounds …

Treatment of neurodegenerative diseases or other central nervous system (CNS) disorders
has always been a significant challenge. The nature of the blood-brain barrier (BBB) limits …

In the field of nasal drug delivery, nose-to-brain delivery is among the most fascinating
applications, directly targeting the central nervous system, bypassing the blood brain barrier …

The malignant brain cancer, glioblastoma multiforme (GBM), is heterogeneous, infiltrative,
and associated with chemo-and radioresistance. Despite pharmacological advances …

Polycaprolactone (PCL) is polymer of 21st centuries. PCL is a biodegradable and
biocompatible polymer used for various healthcare applications. This review explores the …

Cell-penetrating peptides (CPPs) have been discovered to deliver chemical drugs, nucleic
acids, and macromolecules to permeate cell membranes, creating a novel route for …

Abstract Nose-to-brain (N-to-B) delivery offers to protein and peptide drugs the possibility to
reach the brain in a non-invasive way. This article is a comprehensive review of the state-of …

In recent years, there have been a growing number of small and large molecules that could
be used to treat diseases of the central nervous system (CNS). Nose-to-brain delivery can …

Gliomas are the most malignant brain tumors, and their treatment is very challenging
because of the presence of the blood–brain barrier (BBB). Intranasal administration has …

Direct nose-to-brain (N-to-B) delivery enables the rapid transport of drugs to the brain, while
minimizing systemic exposure. The objective of this work was to engineer a nanocarrier …