Biology of Acinetobacter baumannii: Pathogenesis, Antibiotic Resistance Mechanisms, and Prospective Treatment Options

CR Lee, JH Lee, M Park, KS Park, IK Bae… - Frontiers in cellular …, 2017 - frontiersin.org
Acinetobacter baumannii is undoubtedly one of the most successful pathogens responsible
for hospital-acquired nosocomial infections in the modern healthcare system. Due to the …

OXA β-lactamases

BA Evans, SGB Amyes - Clinical microbiology reviews, 2014 - Am Soc Microbiol
The OXA β-lactamases were among the earliest β-lactamases detected; however, these
molecular class D β-lactamases were originally relatively rare and always plasmid …

[HTML][HTML] Antimicrobial resistance in Acinetobacter baumannii: From bench to bedside

MF Lin, CY Lan - World Journal of Clinical Cases: WJCC, 2014 - ncbi.nlm.nih.gov
Acinetobacter baumannii (A. baumannii) is undoubtedly one of the most successful
pathogens in the modern healthcare system. With invasive procedures, antibiotic use and …

Multiresistant Gram-negative bacteria: the role of high-risk clones in the dissemination of antibiotic resistance

N Woodford, JF Turton… - FEMS microbiology …, 2011 - academic.oup.com
Multilocus sequence typing reveals that many bacterial species have a clonal structure and
that some clones are widespread. This underlying phylogeny was not revealed by pulsed …

Colistin resistance of Acinetobacter baumannii: clinical reports, mechanisms and antimicrobial strategies

Y Cai, D Chai, R Wang, B Liang… - Journal of antimicrobial …, 2012 - academic.oup.com
Colistin is the last resort for treatment of multidrug-resistant Acinetobacter baumannii.
Unfortunately, resistance to colistin has been reported all over the world. The highest …

Diversity, epidemiology, and genetics of class D β-lactamases

L Poirel, T Naas, P Nordmann - Antimicrobial agents and …, 2010 - Am Soc Microbiol
Class D β-lactamase-mediated resistance to β-lactams has been increasingly reported
during the last decade. Those enzymes also known as oxacillinases or OXAs are widely …

The Acinetobacter baumannii Oxymoron: Commensal Hospital Dweller Turned Pan-Drug-Resistant Menace

I Roca, P Espinal, X Vila-Farrés, J Vila - Frontiers in microbiology, 2012 - frontiersin.org
During the past few decades Acinetobacter baumannii has evolved from being a commensal
dweller of health-care facilities to constitute one of the most annoying pathogens …

Phosphoethanolamine modification of lipid A in colistin-resistant variants of Acinetobacter baumannii mediated by the pmrAB two-component regulatory system

A Beceiro, E Llobet, J Aranda… - Antimicrobial agents …, 2011 - Am Soc Microbiol
Colistin resistance is rare in Acinetobacter baumannii, and little is known about its
mechanism. We investigated the role of PmrCAB in this trait, using (i) resistant and …

The rise of carbapenem-resistant Acinetobacter baumannii

BA Evans, A Hamouda… - Current pharmaceutical …, 2013 - ingentaconnect.com
Acinetobacter spp. are Gram-negative bacteria that have become one of the most difficult
pathogens to treat. The species A. baumannii, largely unknown 30 years ago, has risen to …

Insights on the Horizontal Gene Transfer of Carbapenemase Determinants in the Opportunistic Pathogen Acinetobacter baumannii

GJ Da Silva, S Domingues - Microorganisms, 2016 - mdpi.com
Horizontal gene transfer (HGT) is a driving force to the evolution of bacteria. The fast
emergence of antimicrobial resistance reflects the ability of genetic adaptation of pathogens …