Multicomponent reactions (MCRs) combine at least three reactants to afford the desired
product in a highly atom-economic way and are therefore viewed as efficient one-pot …

The history of the β-lactam (2-azetidinone) ring, arguably one of the most acclaimed
heterocycles studied over the last century, tells a tale rich in curiosity, serendipity, and …

Reactive intermediates as recognized chemical entities date back for over a century, and
among the earliest examples were simple free radicals, as identified in 1879, when it was …

Evaluating the aromaticity of a molecular system and the influence of this concept on its
properties is a crucial step in the development of novel aromatic systems. Modern …

The synthesis of 2‐azetidinones (β‐lactams) from simple acrylamide starting materials by
visible‐light‐mediated energy transfer catalysis is reported. The reaction features a C (sp3) …

1. Introduction b-Lactam or azetidin-2-one is an important structural motif of the penicillin,
cephalosporin, carbapenem, and carbecephem classes of antibiotics. 1 Naturally occurring …

We report the synthesis of β‐lactams from α‐ketoacylsilanes and imines, which proceeds via
a formal [2+ 2] photochemical cycloaddition with in situ generation of siloxyketene. This mild …

The report by Staudinger in 1907 of the reactions of diphenylketene (1) with
benzylideneaniline (2), benzaldehyde, and cyclopentadiene forming [2þ2] adducts 3–5 …

The carbonylation of carbenes through catalytic cycles is highly desirable due to the
importance of ketene-mediated reactions in organic synthesis. In this investigation, a highly …

Selected developments in the chemistry of heteroaromatic N-oxides since 2001 are
presented in this review. The use of these N-oxides, both in late-transition-metal-catalyzed …