Butyrate, a main product of gut microbial fermentation, has been recognized as an important
mediator of gut microbiota regulation in whole body energy homeostasis. However, the …

Hypothalamic kisspeptin neurons serve as the nodal regulatory centre of reproductive
function. These neurons are subjected to a plethora of regulatory factors that ultimately affect …

Through epigenetic mechanisms cells integrate environmental stimuli to fine-tune gene
expression levels. Mitochondrial function is essential to provide the intermediate metabolites …

The beneficial effects of brown adipose tissue (BAT) are attributed to its capacity to oxidize
metabolites and produce heat, but recent data suggest that secretory properties of BAT may …

Mitochondrial fusion and fission events, collectively known as mitochondrial dynamics, act
as quality control mechanisms to ensure mitochondrial function and fine‐tune cellular …

Brown and beige adipocytes arise from distinct developmental origins. Brown adipose tissue
(BAT) develops embryonically from precursors that also give to skeletal muscle. Beige fat …

Obesity has reached epidemic proportions globally. Although modern adoption of a
sedentary lifestyle coupled with energy-dense nutrition is considered to be the main cause …

As most of the mitochondrial proteome is encoded in the nucleus, mitochondrial functions
critically depend on nuclear gene expression and bidirectional mito-nuclear communication …

Objective The gut microbiota regulates thermogenesis to benefit metabolic homeostasis at
least partially via its metabolite butyrate, and the underlying mechanisms of this regulation …

Traditional treatments for breast cancer fail to address therapy-resistant cancer stem–like
cells that have been characterized by changes in epigenetic regulators such as the lysine …