3′ RNA decay pathways are critical for quality control and regulation of gene expression.
Structural and biochemical studies have provided insights into the key nucleases that carry …

Drosophila eggs are highly polarised cells that use RNA–protein complexes to regulate
storage and translational control of maternal RNAs. Ribonucleoprotein granules are a class …

Meiosis, at the transition between diploid and haploid life cycle phases, is accompanied by
reprograming of cell division machinery and followed by a transition back to mitosis. We …

Mitochondria are central regulators of healthspan and lifespan, yet the intricate
choreography of multiple, tightly controlled steps regulating mitochondrial biogenesis …

The cell interior is packed with macromolecules of mesoscale size, and this crowded milieu
significantly influences cellular physiology. Cellular stress responses almost universally lead …

Cells can store memories of prior experiences to modulate their responses to subsequent
stresses, as seen for the protein kinase A (PKA)–mediated general stress response in yeast …

Asymmetric localization of mRNA is important for cell fate decisions in eukaryotes and
provides the means for localized protein synthesis in a variety of cell types. Here, we show …

Human cytomegalovirus (HCMV) exhibits a complex host-pathogen interaction with
peripheral blood monocytes. We have identified a unique, cell-type specific retrograde-like …

Ethanol (EtOH) is a substantial stressor for Saccharomyces cerevisiae. Data integration from
strains with different phenotypes, including EtOH stress-responsive lncRNAs, are still not …

Gene expression involves regulation of chromatin structure and transcription, as well as
processing of the transcribed mRNA. While there are feedback mechanisms, it is not clear …