The neurotransmitter transporters (NTTs) belonging to the solute carrier 6 (SLC6) gene
family (also referred to as the neurotransmitter-sodium-symporter family or Na+/Cl …

Dopamine is a small and relatively simple molecule that fulfills diverse functions. Within the
brain, it acts as a classical neurotransmitter whose attenuation or overactivity can result in …

Abstract Antidepressants targeting Na+/Cl−-coupled neurotransmitter uptake define a key
therapeutic strategy to treat clinical depression and neuropathic pain. However, identifying …

The classical biogenic amine neurotransmitters—dopamine, noradrenaline, and 5-
hydroxytryptamine—control a variety of functions including locomotion, autonomic function …

Using radioligand binding assays, we determined the equilibrium dissociation constants
(KD's) for 37 antidepressants, three of their metabolites (desmethylcitalopram …

Dopamine (DA) plays a well recognized role in a variety of physiologic functions such as
movement, cognition, mood, and reward. Consequently, many human disorders are due, in …

~ eur~ trffns~~ jssjo~, which represents chemical signalting betzueen neurons, usually fakes
place af highly differenfiated anatomical sfructures catted synapses. To fulfill both the time …

Background The plasma membrane neurotransmitter transporters terminate
neurotransmissions by the reuptake of the released neurotransmitters. The transporters for …

The SLC6 family is a diverse set of transporters that mediate solute translocation across cell
plasma membranes by coupling solute transport to the cotransport of sodium and chloride …

The human dopamine transporter (DAT1) gene contains a variable number of tandem
repeats (VNTR) in its 3′-untranslated region (UTR). The linkage and association between …