Coarse-grained protein models and their applications

S Kmiecik, D Gront, M Kolinski, L Wieteska… - Chemical …, 2016 - ACS Publications
The traditional computational modeling of protein structure, dynamics, and interactions
remains difficult for many protein systems. It is mostly due to the size of protein …

Lost in (clinical) translation: Recent advances in heparin neutralization and monitoring

B Ourri, L Vial - ACS Chemical Biology, 2019 - ACS Publications
The heparin family, which includes unfractionated heparin, low-molecular heparin, and
fondaparinux, is a class of drugs clinically used as intravenous blood thinners. To date …

Multi-component hybrid hydrogels–understanding the extent of orthogonal assembly and its impact on controlled release

VMP Vieira, LL Hay, DK Smith - Chemical science, 2017 - pubs.rsc.org
This paper reports self-assembled multi-component hybrid hydrogels including a range of
nanoscale systems and characterizes the extent to which each component maintains its own …

Nonthrombogenic hydrogel coatings with carbene-cross-linking bioadhesives

HS Nanda, AH Shah, G Wicaksono… - …, 2018 - ACS Publications
Bioadhesives are a current unmet clinical need for mending of blood contacting soft tissues
without inducing thrombosis. Recent development of carbene precursor bioadhesives with …

Electrostatic binding of polyanions using self-assembled multivalent (SAMul) ligand displays–structure–activity effects on DNA/heparin binding

LE Fechner, B Albanyan, VMP Vieira, E Laurini… - Chemical …, 2016 - pubs.rsc.org
This paper reports that modifying the ligands in self-assembled multivalent (SAMul) displays
has an impact on apparent binding selectivity towards two nanoscale biological polyanions …

Heparin versus DNA: chiral preferences in polyanion binding to self-assembled multivalent (SAMul) nanostructures

SM Bromfield, DK Smith - Journal of the American Chemical …, 2015 - ACS Publications
This communication presents simple cationic self-assembling multivalent (SAMul) first
generation dendrons based on l or d lysine, which form identical nanoscale assemblies in …

From fundamental supramolecular chemistry to self-assembled nanomaterials and medicines and back again–how Sam inspired SAMul

DK Smith - Chemical Communications, 2018 - pubs.rsc.org
This feature article provides a personal insight into the research from my group over the past
10 years. In particular, the article explains how, inspired in 2005 by meeting my now …

Bioapplications of acoustic crystals, a review

M Hussain, F Rupp, HP Wendel, FK Gehring - TrAC Trends in Analytical …, 2018 - Elsevier
The acoustic crystal innovation is picking up fame as an emerging equipment for “Point of
Care”(POC) applications in biological part of clinics, while the unprecedented capability of …

Monitoring clinical levels of heparin in human blood samples with an indicator-displacement assay

JP Francoia, R Pascal, L Vial - Chemical Communications, 2015 - pubs.rsc.org
We report that a “tree-like” polymer of lysine is able to form a multi-ligand complex with a
fluorescently labelled peptide, leading to the almost complete extinction of the optical signal …

Emergence of highly-ordered hierarchical nanoscale aggregates on electrostatic binding of self-assembled multivalent (SAMul) cationic micelles with polyanionic …

VMP Vieira, V Liljeström, P Posocco… - Journal of Materials …, 2017 - pubs.rsc.org
We report three surfactants, with cationic N, N-di-(3-aminopropyl)-N-methylamine (DAPMA)
head groups and aliphatic chains connected via an amide linkage, and investigate their …