Cellular and molecular mechanisms mediating methylmercury neurotoxicity and neuroinflammation

JP Novo, B Martins, RS Raposo, FC Pereira… - International journal of …, 2021 - mdpi.com
Methylmercury (MeHg) toxicity is a major environmental concern. In the aquatic reservoir,
MeHg bioaccumulates along the food chain until it is consumed by riverine populations …

Mechanisms of oxidative stress in methylmercury-induced neurodevelopmental toxicity

X Li, J Pan, Y Wei, L Ni, B Xu, Y Deng, T Yang, W Liu - Neurotoxicology, 2021 - Elsevier
Methylmercury (MeHg) is a long-lasting organic environmental pollutant that poses a great
threat to human health. Ingestion of seafood containing MeHg is the most important way by …

[HTML][HTML] Autologous exosome facilitates load and target delivery of bioactive peptides to repair spinal cord injury

N Ran, W Li, R Zhang, C Lin, J Zhang, Z Wei, Z Li… - Bioactive Materials, 2023 - Elsevier
Spinal cord injury (SCI) causes motor, sensory and automatic impairment due to rarely axon
regeneration. Developing effective treatment for SCI in the clinic is extremely challenging …

Neuroprotective effect of deferoxamine on erastin-induced ferroptosis in primary cortical neurons

Y Zhang, BY Fan, YL Pang, WY Shen… - Neural regeneration …, 2020 - journals.lww.com
The iron chelator deferoxamine has been shown to inhibit ferroptosis in spinal cord injury.
However, it is unclear whether deferoxamine directly protects neurons from ferroptotic cell …

Targeted Repair of Spinal Cord Injury Based on miRNA‐124‐3p–Loaded Mesoporous Silica Camouflaged by Stem Cell Membrane Modified with Rabies Virus …

X Fan, L Shi, Z Yang, Y Li, C Zhang, B Bai… - Advanced …, 2024 - Wiley Online Library
Spinal cord injury (SCI) has no effective treatment modalities. It faces a significant global
therapeutical challenge, given its features of poor axon regeneration, progressive local …

Unbalanced ER‐mitochondrial calcium homeostasis promotes mitochondrial dysfunction and associated apoptotic pathways activation in methylmercury exposed rat …

J Pan, Y Wei, L Ni, X Li, Y Deng, B Xu… - … of Biochemical and …, 2022 - Wiley Online Library
Methylmercury (MeHg) is a cumulative environmental pollutant that can easily cross the
blood–brain barrier and cause damage to the brain, mainly targeting the central nervous …

Sex-specific impacts of thimerosal on the behaviors and brain monoaminergic systems in zebrafish (Danio rerio)

X Qiu, Z Su, J Gao, Y Cui, K Dong, K Chen, RJ Zhao… - Aquatic Toxicology, 2024 - Elsevier
Thimerosal (THI) is the most widely used form of organic mercury in pharmaceutical and
personal care products, and has become a major source of ethylmercury pollution in aquatic …

Structural changes observed in the piriform cortex in a rat model of pre-motor Parkinson's disease

M Sancandi, EV Schul, G Economides… - Frontiers in cellular …, 2018 - frontiersin.org
Early diagnosis of Parkinson's disease (PD) offers perhaps, the most promising route to a
successful clinical intervention, and the use of an animal model exhibiting symptoms …

Aqueous Coriandrum sativum L. extract promotes neuroprotection against motor changes and oxidative damage in rat progeny after maternal exposure to …

KE Rodrigues, FR de Oliveira, BRC Barbosa… - Food and Chemical …, 2019 - Elsevier
This study aimed to investigate the effects of Coriandrum sativum aqueous extract (CSAE)
on the rat progeny of mothers exposed to methylmercury (MeHg). The presence of bioactive …

L-ascorbic acid 2-phosphate attenuates methylmercury-induced apoptosis by inhibiting reactive oxygen species accumulation and DNA damage in human SH-SY5Y …

K Zuo, Q Xu, Y Wang, Y Sui, Y Niu, Z Liu, M Liu, X Liu… - Toxics, 2023 - mdpi.com
Methylmercury (MeHg) is a toxin that causes severe neuronal oxidative damage. As vitamin
C is an antioxidant well-known to protect neurons from oxidative damage, our goal was to …