AMPA receptors mediate fast excitatory neurotransmission in the mammalian brain and transduce the binding of presynaptically released glutamate to the opening of a …
V Ismail, LG Zachariassen, A Godwin… - The American Journal of …, 2022 - cell.com
GRIA1 encodes the GluA1 subunit of α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors, which are ligand-gated ion channels that act as excitatory receptors for …
Burst spiking in substantia nigra pars compacta (SNc) dopaminergic neurons is a key signaling event in the circuitry controlling goal-directed behavior. It is widely believed that …
LD Hachem, J Hong, A Velumian, AJ Mothe, CH Tator… - Stem Cell Reports, 2023 - cell.com
The adult spinal cord contains a population of ependymal-derived neural stem/progenitor cells (epNSPCs) that are normally quiescent, but are activated to proliferate, differentiate …
TG Banke, A Barria - Frontiers in synaptic neuroscience, 2020 - frontiersin.org
AMPA-type glutamate receptors (AMPARs) are tetrameric ligand-gated channels made up of combinations of GluA1-4 subunits and play important roles in synaptic transmission and …
FC Cardoso, M Hasan, T Zhao… - Current opinion in …, 2018 - journals.lww.com
Toxins have evolved to induce or inhibit pain by targeting a broad range of ion channels and receptors, including Na V, Ca V, KV, TRP, ASIC, P2X, α-amino-3-hydroxy-5-methyl-4 …
Excessive levels of glutamate activity could potentially damage and kill neurons. Glutamate excitotoxicity is thought to play a critical role in many CNS and retinal diseases. Accordingly …
As a result of competition between species, a multitude of physical adaptations have emerged that confer an evolutionary bene t to the animals that possess them. One …
X Wen, AL Cahill, C Barta, WB Thoreson… - Frontiers in Cellular …, 2018 - frontiersin.org
The predominate type of AMPA receptor expressed in the CNS is impermeable to Ca2+ (CI- AMPAR). However, some AMPA receptors are permeable to Ca2+ (CP-AMPAR) and play …