Computational approaches, including physics-and knowledge-based methods, have
commonly been used to determine the ligand-binding affinity toward SARS-CoV-2 main …

Abstract Indoleamine 2, 3-dioxygenase (IDO1) is a heme-containing enzyme mainly
responsible for the metabolism of tryptophan to kynurenine. To date, the IDO1 inhibitors …

Abstract Indoleamine 2, 3-dioxygenase 1 (IDO1) is an immune checkpoint that degrades L-
tryptophan to kynurenine (Kyn) and enhance immunosuppression, which can be an …

Background: Indazole is a promising structure present in various biological activity
compounds; in particular, many 6-aminoindazole-containing compounds demonstrated …

In this work, we report 14 novel quinazoline derivatives as immune checkpoint inhibitors,
IDO1 and PD-L1. The antitumor screening of synthesized compounds on ovarian cancer …

Abstract Indoleamine 2, 3-dioxygenase 1 (IDO1) is an enzyme participating in tryptophan
metabolism that has been implicated in numerous cancers. In the present study, a series of …

N-heterocyclic compounds are a natural and rich source of pharmacologically active
molecules displaying anti-cancer properties through various antiproliferative mechanisms …

ABSTRACT Indoleamine 2, 3-dioxygenase 1 (IDO1) is an enzyme participating in tryptophan
metabolism that has been implicated in numerous cancers. In the present study, a series of …

Abstract Indoleamine 2, 3-dioxygenase (IDO1) has emerged as a critical immune checkpoint
with profound implications in numerous types of cancer. Dysregulation of IDO1 has …

Tóm tắt Five novel aromatic acetamide bearing 6-amino-1H-indazol scaffold compounds
(IVa-e) were designed and synthesized through foursteps by well-known reactions. These …