By providing spatial, molecular and morphological data over time, live-cell imaging can
provide a deeper understanding of the cellular and signalling events that determine cancer …

Background & Aims Non-alcoholic steatohepatitis (NASH) represents the fastest growing
underlying cause of hepatocellular carcinoma (HCC) and has been shown to impact …

Tissue-resident macrophages adapt to local signals within tissues to acquire specific
functions. Neoplasia transforms the tissue, raising the question as to how the environmental …

Adoptive transfer of genetically engineered chimeric antigen receptor (CAR) T cells is
becoming a promising treatment option for hematological malignancies. However, T cell …

Simple Summary Immunotherapy in glioblastoma has so far failed to yield a survival benefit.
This failure can be attributed to a paucity of immune cells at the tumor site which can be …

Analyses of healthy tissue reveal signatures that identify resident memory CD8+ T cells
(TRM), which survey tissues without recirculating. The density of TRM phenotype cells within …

Imaging and characterizing the dynamics of cellular adhesion in blood samples is of
fundamental importance in understanding biological function. In vitro microscopy methods …

Dysfunction of invariant natural killer T (iNKT) cells contributes to immune resistance of
tumors. Most mechanistic studies focus on their static functional status before or after …

Chimeric antigen receptor (CAR) T cells used for the treatment of B cell malignancies can
identify T cell subsets with superior clinical activity. Here, using infusion products of …

Adoptive transfer of T-cells expressing chimeric antigen receptors (CAR) has shown
remarkable clinical efficacy against advanced B-cell malignancies. Nonetheless, the field of …