Precise spatio–temporal control of gene activity is essential for organismal development,
growth, and survival in a changing environment. Decisive steps in gene regulation involve …

The journey of RNA polymerase II (Pol II) as it transcribes a gene is anything but a smooth
ride. Transcript elongation is discontinuous and can be perturbed by intrinsic regulatory …

The dynamic regulation of transcription elongation by RNA polymerase II (Pol II) is an
integral part of the implementation of gene expression programmes during development. In …

Abstract RNA polymerase II (Pol II) transcribes all protein-coding genes and many
noncoding RNAs in eukaryotic genomes. Although Pol II is a complex, 12-subunit enzyme, it …

Defining direct targets of transcription factors and regulatory pathways is key to
understanding their roles in physiology and disease. We combined SLAM-seq [thiol (SH) …

Regulation by gene-distal enhancers is critical for cell type-specific and condition-specific
patterns of gene expression. Thus, to understand the basis of gene activity in a given cell …

The elongation stage of transcription by RNA polymerase II (RNA Pol II) is central to the
regulation of gene expression in response to developmental and environmental cues in …

Gene transcription by RNA polymerase II (Pol II) is the first step in the expression of the
eukaryotic genome and a focal point for cellular regulation during development …

Control of transcription speed, which influences many co-transcriptional processes, is poorly
understood. We report that PNUTS-PP1 phosphatase is a negative regulator of RNA …

Nuclear receptor-binding SET-domain protein 1 (NSD1), a methyltransferase that catalyzes
H3K36me2, is essential for mammalian development and is frequently dysregulated in …