Neuroinflammatory mediators in acquired epilepsy: an update
Epilepsy is a group of chronic neurological disorders that have diverse etiologies but are
commonly characterized by spontaneous seizures and behavioral comorbidities. Although …
commonly characterized by spontaneous seizures and behavioral comorbidities. Although …
Therapeutic implications of cyclooxygenase (COX) inhibitors in ischemic injury
Introduction Ischemia–reperfusion injury (IRI) is the inexplicable aggravation of cellular
dysfunction that results in blood flow restoration to previously ischemic tissues. COX …
dysfunction that results in blood flow restoration to previously ischemic tissues. COX …
Targeting ep2 receptor for drug discovery: strengths, weaknesses, opportunities, and threats (swot) analysis
T Ganesh - Journal of Medicinal Chemistry, 2023 - ACS Publications
Cyclooxygenase-1 and-2 (COX1 and COX2) derived endogenous ligand prostaglandin-E2
(PGE2) triggers several physiological and pathological conditions. It mediates signaling …
(PGE2) triggers several physiological and pathological conditions. It mediates signaling …
Discovery of 2H-Indazole-3-carboxamide Derivatives as Novel Potent Prostanoid EP4 Receptor Antagonists for Colorectal Cancer Immunotherapy
Z Cheng, Y Wang, Y Zhang, C Zhang… - Journal of Medicinal …, 2023 - ACS Publications
Nowadays, small-molecule drugs have become an indispensable part of tumor
immunotherapy. Accumulating evidence has indicated that specifically blocking PGE2/EP4 …
immunotherapy. Accumulating evidence has indicated that specifically blocking PGE2/EP4 …
[HTML][HTML] Inducible prostaglandin E synthase as a pharmacological target for ischemic stroke
As the inducible terminal enzyme for prostaglandin E2 (PGE 2) synthesis, microsomal PGE
synthase-1 (mPGES-1) contributes to neuroinflammation and secondary brain injury after …
synthase-1 (mPGES-1) contributes to neuroinflammation and secondary brain injury after …
Pleiotropic effects of the COX-2/PGE2 axis in the glioblastoma tumor microenvironment
Glioblastoma (GBM) is the most common and aggressive form of malignant glioma. The
GBM tumor microenvironment (TME) is a complex ecosystem of heterogeneous cells and …
GBM tumor microenvironment (TME) is a complex ecosystem of heterogeneous cells and …
Transient inhibition of microsomal prostaglandin E synthase-1 after status epilepticus blunts brain inflammation and is neuroprotective
Status epilepticus (SE) in humans is characterized by prolonged convulsive seizures that
are generalized and often difficult to control. The current antiseizure drugs (ASDs) aim to …
are generalized and often difficult to control. The current antiseizure drugs (ASDs) aim to …
[HTML][HTML] Prostaglandin E2 in neuroblastoma: Targeting synthesis or signaling?
Neuroblastoma (NB) is the most common pediatric extracranial solid tumor arising from
neural crest cells of the developing sympathetic nervous system. Despite marked advances …
neural crest cells of the developing sympathetic nervous system. Despite marked advances …
Alterations of plasma pro-inflammatory cytokine levels in children with refractory epilepsies
T Gakharia, S Bakhtadze, M Lim, N Khachapuridze… - Children, 2022 - mdpi.com
Paediatric epilepsy is a multifaceted neurological disorder with various aetiologies. Up to
30% of patients are considered drug-resistant. The background impact of interfering …
30% of patients are considered drug-resistant. The background impact of interfering …
Distinct cell-specific roles of NOX2 and MyD88 in epileptogenesis
It is well established that temporal lobe epilepsy (TLE) is often related to oxidative stress and
neuroinflammation. Both processes subserve alterations observed in epileptogenesis and …
neuroinflammation. Both processes subserve alterations observed in epileptogenesis and …