By the time a tumor reaches clinical detectability, it contains around 108–109 cells.
However, during tumor formation, significant cell loss occurs due to cell death. In some …

In the past decade, remarkable progress in cancer medicine has been achieved by the
development of treatments that target DNA sequence variants. However, a purely genetic …

Isocitrate dehydrogenase (IDH) mutants define a class of gliomas that are initially slow-
growing but inevitably progress to fatal disease. To characterize their malignant cell …

Current methods for analyzing chromatin architecture are not readily scalable to
heterogeneous tissues. Here we introduce Droplet Hi-C, which uses a commercial …

Enhancer-gene communication is dependent on topologically associating domains (TADs)
and boundaries enforced by the CCCTC-binding factor (CTCF) insulator, but the underlying …

Glioblastoma (GBM) is one of the most lethal central nervous systems (CNS) tumours in
adults. As supplements to standard of care (SOC), various immunotherapies improve the …

During mammalian embryogenesis, both the 5-cytosine DNA methylation (5meC) landscape
and three dimensional (3D) chromatin architecture are profoundly remodeled during a …

Gender plays a crucial role in the occurrence and development of cancer, as well as in the
metabolism of nutrients and energy. Men and women display significant differences in the …

Glioma is a type of aggressive and incurable brain tumor. Patients with glioma are highly
resistant to all types of therapies, including immunotherapies. Epigenetic reprogramming is …

Simple Summary The human genome produces various types of RNA molecules. A
significant portion of these are long non-coding RNAs (lncRNAs) exceeding 200 nts without …