Immune dysregulation as a driver of idiopathic pulmonary fibrosis

K Shenderov, SL Collins, JD Powell… - The Journal of clinical …, 2021 - Am Soc Clin Investig
Idiopathic pulmonary fibrosis (IPF) affects hundreds of thousands of people worldwide,
reducing their quality of life and leading to death from respiratory failure within years of …

In vitro co-culture studies and the crucial role of fibroblast-immune cell crosstalk in IPF pathogenesis

F Thiam, S Phogat, FA Abokor, ET Osei - Respiratory Research, 2023 - Springer
IPF is a fatal lung disease characterized by intensive remodeling of lung tissue leading to
respiratory failure. The remodeling in IPF lungs is largely characterized by uncontrolled …

[HTML][HTML] Clinical molecular imaging of pulmonary CXCR4 expression to predict outcome of pirfenidone treatment in idiopathic pulmonary fibrosis

T Derlin, B Jaeger, D Jonigk, RM Apel, J Freise… - Chest, 2021 - Elsevier
Background Idiopathic pulmonary fibrosis (IPF) is a progressive disease for which two
antifibrotic drugs recently were approved. However, an unmet need exists to predict …

[HTML][HTML] Clinical significance of the immune cell landscape in hepatocellular carcinoma patients with different degrees of fibrosis

X Tang, Z Shu, W Zhang, L Cheng, J Yu… - Annals of …, 2019 - ncbi.nlm.nih.gov
Background The major causes of morbidity and mortality of patients with chronic liver
disease are liver fibrosis and cirrhosis. Previous studies have been concerned with immune …

Profiles of immune cell infiltration and their clinical significance in head and neck squamous cell carcinoma

Y Jin, X Qin - International immunopharmacology, 2020 - Elsevier
It is well established that there exist comprehensive interactions between tumor immunology
and tumor biology. Tumor-infiltrating immune cells (TIICs) have been appealing therapeutic …

[HTML][HTML] Peripheral neutrophils and naive CD4 T cells predict the development of heart failure following acute myocardial infarction: A bioinformatic study

C Yu, W Zhou - Revista Portuguesa de Cardiologia (English Edition), 2021 - Elsevier
Introduction Heart failure (HF) secondary to acute myocardial infarction (AMI) is still a
worldwide problem with a high mortality rate. The current study aimed to explore early and …

Activation of the P2RX7/IL-18 pathway in immune cells attenuates lung fibrosis

SJ dit Hreich, T Juhel, S Leroy, A Ghinet, F Brau… - Elife, 2024 - elifesciences.org
Idiopathic pulmonary fibrosis (IPF) is an aggressive interstitial lung disease associated with
progressive and irreversible deterioration of respiratory functions that lacks curative …

Monocyte count and the risk for acute exacerbation of fibrosing interstitial lung disease: a retrospective cohort study

K Kawamura, K Ichikado, K Anan… - Chronic Respiratory …, 2020 - journals.sagepub.com
Recent studies have suggested that an increased peripheral monocyte count predicts a poor
outcome in fibrosing interstitial lung disease (ILD). However, the association between an …

A novel prognostic signature based on metabolism-related genes to predict survival and guide personalized treatment for head and neck squamous carcinoma

Y Li, Y Weng, Y Pan, Z Huang, X Chen, W Hong… - Frontiers in …, 2021 - frontiersin.org
Metabolic reprogramming contributes to patient prognosis. Here, we aimed to reveal the
comprehensive landscape in metabolism of head and neck squamous carcinoma (HNSCC) …

The immune mechanisms of acute exacerbations of idiopathic pulmonary fibrosis

T Chen, W Sun, Z Xu - Frontiers in Immunology, 2024 - frontiersin.org
Acute exacerbations of idiopathic pulmonary fibrosis (AE-IPF) are the leading cause of
mortality among patients with IPF. There is still a lack of effective treatments for AE-IPF …