Hepatitis A is a vaccine-preventable infection caused by the hepatitis A virus (HAV). Over 150 million new infections of hepatitis A occur annually. HAV causes an acute inflammatory …
Advances in nuclease-based gene-editing technologies have enabled precise, stable, and systematic genetic engineering of glycosylation capacities in mammalian cells, opening up a …
G Cao, W Jing, J Liu, M Liu - Hepatology international, 2021 - Springer
Background and purpose Despite decades of improved sanitation and hygiene measures and vaccine introduction, hepatitis A has been spread through numerous outbreaks globally …
T Shiota, Z Li, GY Chen, KL McKnight, T Shirasaki… - Science …, 2023 - science.org
Virus-induced changes in host lipid metabolism are an important but poorly understood aspect of viral pathogenesis. By combining nontargeted lipidomics analyses of infected cells …
CL Hsu, Y Duan, DE Fouts, B Schnabl - Journal of hepatology, 2021 - Elsevier
Humans harbour a large quantity of microbes in the intestinal tract and have evolved symbiotic relationships with many of them. However, several specific bacterial pathobionts …
Y Li, I Misumi, T Shiota, L Sun… - Proceedings of the …, 2022 - National Acad Sciences
Despite excellent vaccines, resurgent outbreaks of hepatitis A have caused thousands of hospitalizations and hundreds of deaths within the United States in recent years. There is no …
Hepatitis A is an acute infection of the liver, which is mostly asymptomatic in children and increases the severity with age. Although in most patients the infection resolves completely …
N Cifuentes-Munoz, F El Najjar, RE Dutch - Advances in virus research, 2020 - Elsevier
A critical step in the life cycle of a virus is spread to a new target cell, which generally involves the release of new viral particles from the infected cell which can then initiate …
T Xia, X Wu, E Hong, K Jung, CJ Lai, MJ Kwak… - PLoS …, 2023 - journals.plos.org
Due to climate changes, there has been a large expansion of emerging tick-borne zoonotic viruses, including Heartland bandavirus (HRTV) and Dabie bandavirus (DBV). As etiologic …