Gene delivery nanoparticles to modulate angiogenesis
Angiogenesis is naturally balanced by many pro-and anti-angiogenic factors while an
imbalance of these factors leads to aberrant angiogenesis, which is closely associated with …
imbalance of these factors leads to aberrant angiogenesis, which is closely associated with …
Tyrosine kinase blocking collagen IV–derived peptide suppresses ocular neovascularization and vascular leakage
R Lima e Silva, Y Kanan, AC Mirando, J Kim… - Science translational …, 2017 - science.org
Vascular endothelial growth factor (VEGF)–neutralizing proteins provide benefit in several
retinal and choroidal vascular diseases, but some patients still experience suboptimal …
retinal and choroidal vascular diseases, but some patients still experience suboptimal …
Molecular docking studies of a cyclic octapeptide-cyclosaplin from sandalwood
Natural products from plants, such as chemopreventive agents, attract huge attention
because of their low toxicity and high specificity. The rational drug design in combination …
because of their low toxicity and high specificity. The rational drug design in combination …
Biomimetic peptide display from a polymeric nanoparticle surface for targeting and antitumor activity to human triple‐negative breast cancer cells
EM Bressler, J Kim, RB Shmueli… - … Research Part A, 2018 - Wiley Online Library
While poly (lactic‐co‐glycolic acid)‐block‐polyethylene glycol (PLGA‐PEG) nanoparticles
(NPs) can encapsulate drug cargos and prolong circulation times, they show nonspecific …
(NPs) can encapsulate drug cargos and prolong circulation times, they show nonspecific …
Inhibition of breast cancer growth and metastasis by a biomimetic peptide
Metastasis is the main cause of mortality in cancer patients. Though there are many anti-
cancer drugs targeting primary tumor growth, anti-metastatic agents are rarely developed …
cancer drugs targeting primary tumor growth, anti-metastatic agents are rarely developed …
Computational modeling of synergistic interaction between αVβ3 integrin and VEGFR2 in endothelial cells: Implications for the mechanism of action of angiogenesis …
Cooperation between VEGFR2 and integrin αVβ3 is critical for neovascularization in wound
healing, cardiovascular ischemic diseases, ocular diseases, and tumor angiogenesis. In the …
healing, cardiovascular ischemic diseases, ocular diseases, and tumor angiogenesis. In the …
Anisotropic poly (lactic-co-glycolic acid) microparticles enable sustained release of a peptide for long-term inhibition of ocular neovascularization
Leading causes of vision loss include neovascular age-related macular degeneration
(NVAMD) and macular edema (ME), which both require frequent intravitreal injections for …
(NVAMD) and macular edema (ME), which both require frequent intravitreal injections for …
Regulation of the tumor immune microenvironment and vascular normalization in TNBC murine models by a novel peptide
AC Mirando, A Patil, CI Rafie, BJ Christmas… - …, 2020 - Taylor & Francis
Triple-negative breast cancer (TNBC) is a highly metastatic and aggressive disease with
limited treatment options. Recently, the combination of the immune checkpoint inhibitor (ICI) …
limited treatment options. Recently, the combination of the immune checkpoint inhibitor (ICI) …
Anti-angiogenic collagen IV-derived peptide target engagement with αvβ3 and α5β1 in ocular neovascularization models
AXT107, a collagen-derived peptide that binds integrins α v β 3 and α 5 β 1 with high affinity,
suppresses vascular endothelial growth factor (VEGF) signaling, promotes angiopoietin 2 …
suppresses vascular endothelial growth factor (VEGF) signaling, promotes angiopoietin 2 …
Gel-forming therapeutic peptide exhibits sustained delivery and efficacy in a mouse model of triple-negative breast cancer
Triple-negative breast cancer (TNBC) is a particularly aggressive and invasive subtype of
breast cancer that represents a major cause of death of women worldwide. Here we …
breast cancer that represents a major cause of death of women worldwide. Here we …