The development of osteoarthritis (OA) correlates with a rise in the number of senescent
cells in joint tissues, and the senescence-associated secretory phenotype (SASP) has been …

Osteoarthritis (OA) is an age-related cartilage degenerative disease, and chondrocyte
senescence has been extensively studied in recent years. Increased numbers of senescent …

Knee osteoarthritis (KOA) is one of the most common degenerative diseases, and its core
feature is the degeneration and damage of articular cartilage. The cartilage degeneration of …

Osteoarthritis (OA) has been recognized as an age-related degenerative disease commonly
seen in the elderly that affects the whole “organ” including cartilage, subchondral bone …

Objective To test the hypothesis that an altered gut microbiota (dysbiosis) plays a role in
obesity‐associated osteoarthritis (OA). Methods Stool and blood samples were collected …

Osteoarthritis (OA) is a degenerative joint disorder associated with inflammation, functional
disability, and high socioeconomic costs. The development of effective therapies against …

Osteoarthritis (OA) is the most prevalent degenerative joint disease in the elderly.
Accumulation of evidence has suggested that chondrocyte senescence plays a significant …

Over recent decades, the field of cellular senescence has attracted considerable attention
due to its association with aging, the development of age-related diseases and cancer …

Mitochondrial function is impaired in osteoarthritis (OA) but its impact on cartilage catabolism
is not fully understood. Here, we investigated the molecular mechanism of mitochondrial …

Background Fibrosis is a tissue damage repair response caused by multiple pathogenic
factors which could occur in almost every apparatus and leading to the tissue structure …