The ability of chemical modifications of single nucleotides to alter the electrostatic charge,
hydrophobic surface and base pairing of RNA molecules is exploited for the clinical use of …

Fragile X mental retardation protein (FMRP) is the product of the fragile X mental retardation
1 gene (FMR1), a gene that—when epigenetically inactivated by a triplet nucleotide repeat …

Modifications of RNA affect its function and stability. RNA editing is unique among these
modifications because it not only alters the cellular fate of RNA molecules but also alters …

Abstract Adenosine-to-inosine (A-to-I) RNA editing is a conserved post-transcriptional
mechanism mediated by ADAR enzymes that diversifies the transcriptome by altering …

One of the most prevalent forms of post-transcritpional RNA modification is the conversion of
adenosine nucleosides to inosine (A-to-I), mediated by the ADAR family of enzymes. The …

Abstract Adenosine-to-inosine (A-to-I) editing, mediated by the ADAR enzymes, diversifies
the transcriptome by altering RNA sequences. Recent studies reported global changes in …

Topoisomerases are crucial for solving DNA topological problems, but they have not been
linked to RNA metabolism. Here we show that human topoisomerase 3β (Top3β) is an RNA …

Abstract Adenosine-to-inosine (A-to-I) RNA editing, in which genomically encoded
adenosine is changed to inosine in RNA, is catalyzed by adenosine deaminase acting on …

The accurate and thorough genome-wide detection of adenosine-to-inosine editing, a
biologically indispensable process, has proven challenging. Here, we present a discovery …

The intrinsic cellular heterogeneity and molecular complexity of the mammalian nervous
system relies substantially on the dynamic nature and spatiotemporal patterning of gene …