The prevalence of heart failure is on the rise and imposes a major health threat, in part, due
to the rapidly increased prevalence of overweight and obesity. To this point …

CXC motif chemokine receptor type 4 (CXCR4) is associated with normal and abnormal
development, including oncogenesis. The ligand of CXCR4 is stromal cell-derived factor …

Aging constitutes a significant risk factor for fibrosis, and idiopathic pulmonary fibrosis (IPF)
is characteristically associated with advancing age. We propose that age‐dependent defects …

Cardiovascular disease (CVD) is one of the predominant causes of death and morbidity.
Mitochondria play a key role in maintaining cardiac energy metabolism. However …

Abstract Background Long noncoding RNA (LncRNA) metastasis-associated lung
adenocarcinoma transcript 1 (MALAT1) is involved in the development of acute myocardial …

Sustained cardiac hypertrophy is a major cause of heart failure (HF) and death. Recent
studies have demonstrated that resveratrol (RES) exerts a protective role in hypertrophic …

Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiovascular disorder,
affecting 1 in 500 people in the general population. Although characterized by asymmetric …

Here, we report inducible mosaic animal for perturbation (iMAP), a transgenic platform
enabling in situ CRISPR targeting of at least 100 genes in parallel throughout the mouse …

Patients with diabetes are vulnerable to MI/R (myocardial ischaemia/reperfusion) injury, but
are not responsive to IPostC (ischaemic post-conditioning) which activates PI3K …

Autophagy is an evolutionarily conserved process used by the cell to degrade cytoplasmic
contents for quality control, survival for temporal energy crisis, and catabolism and recycling …