Cryptococcal meningitis is the leading cause of adult meningitis in sub-Saharan Africa, and
contributes up to 20% of AIDS-related mortality in low-income and middle-income countries …

The leishmaniases are a group of four vector-borne neglected tropical diseases (NTDs) with
1.6 billion people in some 100 countries at risk. They occur in certain eco-epidemiological …

Parenteral amphotericin B has been considered as first-line therapy in the treatment of
systemic fungal and parasitic infections, however its use has been associated with a number …

Amphotericin B (AmpB) is a polyene macrolide antibiotic used in the treatment of blood-
borne parasitic and fungal infections. However, its use, particularly in the developing world …

Background Visceral leishmaniasis (VL) is a parasitic infection (also called kala-azar in
South Asia) caused by Leishmania donovani that is a considerable threat to public health in …

Background Visceral leishmaniasis (VL) can be fatal without timely diagnosis and treatment.
Treatment efficacies vary due to drug resistance, drug toxicity and co-morbidities. It is …

Leishmaniasis clinical spectrum ranges from cryptic infection to fatal visceral leishmaniasis.
Cryptic infection can be found in blood donors from areas endemic for leishmaniasis all over …

Purpose To investigate the biodistribution of amphotericin B (AmB) in mice and rats
following administration of liposomal AmB (AmBisome®) using a physiologically-based …

Introduction Cutaneous leishmaniasis (CL) is a vector-borne disease of increasing
importance in northeastern Brazil. It is known that sandflies, which spread the causative …

Paromomycin (PMM) has recently been introduced for treatment of visceral leishmaniasis in
India. Although no clinical resistance has yet been reported, proactive vigilance should be …