Non-alcoholic fatty liver disease (NAFLD) is a major health issue worldwide, frequently
associated with obesity and type 2 diabetes. Steatosis is the initial stage of the disease …

Mammals undergo regular cycles of fasting and feeding that engage dynamic transcriptional
responses in metabolic tissues. Here we review advances in our understanding of the gene …

Somatic mutations in nonmalignant tissues accumulate with age and injury, but whether
these mutations are adaptive on the cellular or organismal levels is unclear. To interrogate …

There is a wide variety of kinds of lipids, and complex structures which determine the
diversity and complexity of their functions. With the basic characteristic of water insolubility …

The lifespan extension induced by 40% caloric restriction (CR) in rodents is accompanied by
postponement of disease, preservation of function, and increased stress resistance. Whether …

Adaptations to infectious and dietary pressures shape mammalian physiology and disease
risk. How such adaptations affect sex-biased diseases remains insufficiently studied. In this …

In mammals, circadian rhythms are entrained to the light cycle and drive daily oscillations in
levels of NAD+, a cosubstrate of the class III histone deacetylase sirtuin 1 (SIRT1) that …

Growth hormone (GH) is critical for achieving normal structural growth. In addition, GH plays
an important role in regulating metabolic function. GH acts through its GH receptor (GHR) to …

Males and females exhibit striking differences in the prevalence of metabolic traits including
hepatic steatosis, a key driver of cardiometabolic morbidity and mortality. RNA methylation is …

Atherosclerosis, a chief pathogenic factor of cardiovascular disease, is associated with many
factors including inflammation, dyslipidemia, and oxidative stress. Peroxisome proliferator …