Meiosis is the cell division that reshuffles genetic information between generations.
Recently, much progress has been made in understanding this process; in particular, the …

Meiosis halves diploid chromosome numbers to haploid levels that are essential for sexual
reproduction in most eukaryotes. Meiotic recombination ensures the formation of bivalents …

Double-strand breaks (DSBs) in heterochromatic repetitive DNAs pose significant threats to
genome integrity, but information about how such lesions are processed and repaired is …

In G 0 and G 1, DNA double strand breaks are repaired by nonhomologous end joining,
whereas in S and G 2, they are also repaired by homologous recombination. The human …

DNA double-strand breaks are repaired by different mechanisms, including homologous
recombination and nonhomologous end-joining. DNA-end resection, the first step in …

DNA double-strand breaks (DSBs) are repaired by two principal mechanisms: non-
homologous end-joining (NHEJ) and homologous recombination (HR). HR is the most …

Double-strand breaks (DSBs) are deleterious DNA lesions and if left unrepaired result in
severe genomic instability. Cells use two main pathways to repair DSBs: homologous …

BRCA1 plays an important role in the homologous recombination (HR)-mediated DNA
double-strand break (DSB) repair, but the mechanism is not clear. Here we describe that …

To combat DNA damage, organisms mount a DNA damage response (DDR) that results in
cell cycle regulation, DNA repair and, in severe cases, cell death. Underscoring the …

The carboxy-terminal binding protein (CtBP)-interacting protein (CtIP) is known to function in
5′ strand resection during homologous recombination, similar to the budding yeast Sae2 …