There has been extensive progress in understanding the cellular and molecular
mechanisms of inflammation and immune regulation in allergic diseases of the skin and …

Atopic dermatitis (AD) is a common, chronic, relapsing, inflammatory skin disease that
affects children and adults. Until recently, the only Food and Drug Administration–approved …

STAT6 (signal transducer and activator of transcription 6) is a transcription factor that plays a
central role in the pathophysiology of allergic inflammation. We have identified 16 patients …

In addition to susceptibility to infections, conventional primary immunodeficiency disorders
(PIDs) and inborn errors of immunity (IEI) can cause immune dysregulation, manifesting as …

Autoimmunity and immunodeficiency were previously considered to be mutually exclusive
conditions; however, increased understanding of the complex immune regulatory and …

Autosomal recessive CARD9 deficiency underlies life-threatening, invasive fungal infections
in otherwise healthy individuals normally resistant to other infectious agents. In less than 10 …

Background & Aims A proportion of infants and young children with inflammatory bowel
diseases (IBDs) have subtypes associated with a single gene variant (monogenic IBD). We …

Dedicator of cytokinesis (DOCK) proteins constitute a family of evolutionarily conserved
guanine nucleotide exchange factors (GEFs) for the Rho family of GTPases. Although DOCK …

Purpose The etiology of 80% of patients with primary antibody deficiency (PAD), the second
most common type of human immune system disorder after human immunodeficiency virus …

The total number of acquired melanocytic nevi on the skin is strongly correlated with
melanoma risk. Here we report a meta-analysis of 11 nevus GWAS from Australia …