Over the past year, vertebrate GATA factors have been found to participate directly in several
signal-transduction pathways. Smad3, phosphorylated by TGF-β signalling, interacts with …

It has long been understood that many of the same manipulations that increase longevity in
Caenorhabditis elegans also increase resistance to various acute stressors, and vice-versa; …

The C. elegans genome has been completely sequenced, and the developmental anatomy
of this model organism is described at single-cell resolution. Here we utilize strategies that …

Complex biological processes such as embryogenesis require precise coordination of cell
differentiation programs across both space and time. Using protein-fusion fluorescent …

The structural maintenance of chromosome (SMC) complexes—cohesin and condensins—
are crucial for chromosome separation and compaction during cell division. During the …

Although the molting cycle is a hallmark of insects and nematodes, neither the endocrine
control of molting via size, stage, and nutritional inputs nor the enzymatic mechanism for …

To define the C. elegans aging process at the molecular level, we used DNA microarray
experiments to identify a set of 1294 age-regulated genes and found that the GATA …

Encounters with pathogens provoke changes in gene transcription that are an integral part
of host innate immune responses. In recent years, studies with invertebrate model …

Many mutations, including those that cause disease, only have a detrimental effect in a
subset of individuals. The reasons for this are usually unknown, but may include additional …

Multinucleate cells are widespread in nature, yet the mechanism by which cells fuse their
plasma membranes is poorly understood. To identify animal fusogens, we performed new …