Patterns of linkage disequilibrium in the human genome

KG Ardlie, L Kruglyak, M Seielstad - Nature Reviews Genetics, 2002 - nature.com
Particular alleles at neighbouring loci tend to be co-inherited. For tightly linked loci, this
might lead to associations between alleles in the population—a property known as linkage …

Estimating divergence times from molecular data on phylogenetic and population genetic timescales

BS Arbogast, SV Edwards, J Wakeley… - Annual review of …, 2002 - annualreviews.org
▪ Abstract Molecular clocks have profoundly influenced modern views on the timing of
important events in evolutionary history. We review recent advances in estimating …

Genomic scans for selective sweeps using SNP data

R Nielsen, S Williamson, Y Kim, MJ Hubisz… - Genome …, 2005 - genome.cshlp.org
Detecting selective sweeps from genomic SNP data is complicated by the intricate
ascertainment schemes used to discover SNPs, and by the confounding influence of the …

Linkage disequilibrium as a signature of selective sweeps

Y Kim, R Nielsen - Genetics, 2004 - academic.oup.com
The hitchhiking effect of a beneficial mutation, or a selective sweep, generates a unique
distribution of allele frequencies and spatial distribution of polymorphic sites. A composite …

[PDF][PDF] Predicting the landscape of recombination using deep learning

JR Adrion, JG Galloway, AD Kern - Molecular biology and …, 2020 - academic.oup.com
Accurately inferring the genome-wide landscape of recombination rates in natural
populations is a central aim in genomics, as patterns of linkage influence everything from …

The signature of positive selection at randomly chosen loci

M Przeworski - Genetics, 2002 - academic.oup.com
In Drosophila and humans, there are accumulating examples of loci with a significant excess
of high-frequency-derived alleles or high levels of linkage disequilibrium, relative to a …

Identification of selection signatures in cattle breeds selected for dairy production

A Stella, P Ajmone-Marsan, B Lazzari, P Boettcher - Genetics, 2010 - academic.oup.com
The genomics revolution has spurred the undertaking of HapMap studies of numerous
species, allowing for population genomics to increase the understanding of how selection …

Molecular Evolution of Sex-Biased Genes in Drosophila

Z Zhang, TM Hambuch, J Parsch - Molecular Biology and …, 2004 - academic.oup.com
Studies of morphology, interspecific hybridization, protein/DNA sequences, and levels of
gene expression have suggested that sex-related characters (particularly those involved in …

Progress and prospects in mapping recent selection in the genome

KR Thornton, JD Jensen, C Becquet, P Andolfatto - Heredity, 2007 - nature.com
One of the central goals of evolutionary biology is to understand the genetic basis of
adaptive evolution. The availability of nearly complete genome sequences from a variety of …

A Large Panel of Drosophila simulans Reveals an Abundance of Common Variants

SA Signor, FN New, S Nuzhdin - Genome biology and evolution, 2018 - academic.oup.com
The rapidly expanding availability of large NGS data sets provides an opportunity to
investigate population genetics at an unprecedented scale. Drosophila simulans is the sister …