Cutting-edge advances in tailoring size, shape, and functionality of nanoparticles and nanostructures: A review

V Harish, MM Ansari, D Tewari, AB Yadav… - Journal of the Taiwan …, 2023 - Elsevier
Background: The versatility and immense potential of nanoparticles and nanostructures
have made them crucial building blocks for a wide range of applications. Achieving precise …

Why nanoparticles prefer liver macrophage cell uptake in vivo

W Ngo, S Ahmed, C Blackadar, B Bussin, Q Ji… - Advanced Drug Delivery …, 2022 - Elsevier
Effective delivery of therapeutic and diagnostic nanoparticles is dependent on their ability to
accumulate in diseased tissues. However, most nanoparticles end up in liver macrophages …

[HTML][HTML] Nanoparticle biodistribution coefficients: A quantitative approach for understanding the tissue distribution of nanoparticles

M Kumar, P Kulkarni, S Liu, N Chemuturi… - Advanced Drug Delivery …, 2023 - Elsevier
The objective of this manuscript is to provide quantitative insights into the tissue distribution
of nanoparticles. Published pharmacokinetics of nanoparticles in plasma, tumor and 13 …

Extracellular vesicles: Emerging anti-cancer drugs and advanced functionalization platforms for cancer therapy

M Wu, M Wang, H Jia, P Wu - Drug Delivery, 2022 - Taylor & Francis
Increasing evidences show that unmodified extracellular vesicles (EVs) derived from various
cells can effectively inhibit the malignant progression of different types of tumors by …

Central nervous system delivery of molecules across the blood-brain barrier

F Gosselet, RA Loiola, A Roig, A Rosell… - Neurochemistry …, 2021 - Elsevier
Therapies targeting neurological conditions such as Alzheimer's or Parkinson's diseases are
hampered by the presence of the blood-brain barrier (BBB). During the last decades, several …

Efficacy and immune response elicited by gold nanoparticle-based nanovaccines against infectious diseases

A Sengupta, M Azharuddin, N Al-Otaibi, J Hinkula - Vaccines, 2022 - mdpi.com
The use of nanoparticles for developing vaccines has become a routine process for
researchers and pharmaceutical companies. Gold nanoparticles (GNPs) are chemical inert …

Nanotherapeutic heterogeneity: sources, effects, and solutions

J Morla‐Folch, A Ranzenigo, ZA Fayad, AJP Teunissen - Small, 2024 - Wiley Online Library
Nanomaterials have revolutionized medicine by enabling control over drugs'
pharmacokinetics, biodistribution, and biocompatibility. However, most nanotherapeutic …

Optimizing the polymer cloak for upconverting nanoparticles: an evaluation of bioactivity and optical performance

L Zhang, C Chen, SS Tay, S Wen, C Cao… - … Applied Materials & …, 2021 - ACS Publications
The ability of upconversion nanoparticles (UCNPs) to convert low-energy near-infrared
(NIR) light into high-energy visible-ultraviolet light has resulted in their development as …

The Role of in silico Research in Developing Nanoparticle-Based Therapeutics

MK Jayasinghe, CY Lee, TTT Tran, R Tan… - Frontiers in Digital …, 2022 - frontiersin.org
Nanoparticles (NPs) hold great potential as therapeutics, particularly in the realm of drug
delivery. They are effective at functional cargo delivery and offer a great degree of …

In vivo fate of liposomes after subconjunctival ocular delivery

SY Chaw, W Novera, AM Chacko, TTL Wong… - Journal of Controlled …, 2021 - Elsevier
Subconjunctival administration of nanocarriers presents an alternative drug delivery strategy
to overcome blood-ocular barriers to enhance drug bioavailability to specific parts of the eye …