Malformations of cortical development (MCDs) are neurodevelopmental disorders that result
from abnormal development of the cerebral cortex in utero. MCDs place a substantial …

Across different cell types and tissues, microtubules are assembled from highly conserved
dimers of α‐and β‐tubulin. Despite their highly similar structures, microtubules have …

Complex cortical malformations associated with mutations in tubulin genes: TUBA1A,
TUBA8, TUBB2B, TUBB3, TUBB5 and TUBG1 commonly referred to as tubulinopathies, are …

A large number of genes encoding for tubulin proteins are expressed in the developing
brain. Each is subject to specific spatial and temporal expression patterns. However, most …

The basal ganglia and thalami are paired deep grey matter structures with extensive
metabolic activity that renders them susceptible to injury by various diseases. Most …

Complex cortical malformations associated with mutations in tubulin genes are commonly
referred to as “Tubulinopathies”. To further characterize the mutation frequency and …

Polymicrogyria (PMG) is one of the most common malformations of cortical development. It is
characterized by overfolding of the cerebral cortex and abnormal cortical layering. It is a …

Tubulins, and microtubule polymers into which they incorporate, play critical mechanical
roles in neuronal function during cell proliferation, neuronal migration, and postmigrational …

Mutations causing dysfunction of tubulins and microtubule-associated proteins, also known
as tubulinopathies, are a group of recently described entities that lead to complex brain …

The tubulin gene family is mainly expressed in post-mitotic neurons during cortical
development with a specific spatial and temporal expression pattern. Members of this family …