[HTML][HTML] Orphan G protein-coupled receptors: The role in CNS disorders
There are various types of receptors in the central nervous system (CNS). G protein-coupled
receptors (GPCRs) have the highest expression with a wide range of physiological …
receptors (GPCRs) have the highest expression with a wide range of physiological …
Orphan G protein-coupled receptor GPR37 as an emerging therapeutic target
G protein-coupled receptors (GPCRs) are successful druggable targets, making up around
35% of all FDA-approved medications. However, a large number of receptors remain …
35% of all FDA-approved medications. However, a large number of receptors remain …
A Noelin-organized extracellular network of proteins required for constitutive and context-dependent anchoring of AMPA-receptors
S Boudkkazi, J Schwenk, N Nakaya, A Brechet… - Neuron, 2023 - cell.com
Information processing and storage in the brain rely on AMPA-receptors (AMPARs) and their
context-dependent dynamics in synapses and extra-synaptic sites. We found that distribution …
context-dependent dynamics in synapses and extra-synaptic sites. We found that distribution …
Puromycin reactivity does not accurately localize translation at the subcellular level
Puromycin is a tyrosyl-tRNA mimic that blocks translation by labeling and releasing
elongating polypeptide chains from translating ribosomes. Puromycin has been used in …
elongating polypeptide chains from translating ribosomes. Puromycin has been used in …
Satellite glial GPR37L1 and its ligand maresin 1 regulate potassium channel signaling and pain homeostasis
G protein–coupled receptor 37-like 1 (GPR37L1) is an orphan GPCR with largely unknown
functions. Here, we report that Gpr37l1/GRP37L1 ranks among the most highly expressed …
functions. Here, we report that Gpr37l1/GRP37L1 ranks among the most highly expressed …
Glio‐and neuro‐protection by prosaposin is mediated by orphan G‐protein coupled receptors GPR37L1 and GPR37
B Liu, V Mosienko, B Vaccari Cardoso, D Prokudina… - Glia, 2018 - Wiley Online Library
Discovery of neuroprotective pathways is one of the major priorities for neuroscience.
Astrocytes are natural neuroprotectors and it is likely that brain resilience can be enhanced …
Astrocytes are natural neuroprotectors and it is likely that brain resilience can be enhanced …
[HTML][HTML] Protective effects of GPR37 via regulation of inflammation and multiple cell death pathways after ischemic stroke in mice
Abstract GPCR 37 (GPR37) is a GPCR expressed in the CNS; its physiological and
pathophysiological functions are largely unknown. We tested the role of GPR37 in the …
pathophysiological functions are largely unknown. We tested the role of GPR37 in the …
Mice lacking full length Adgrb1 (Bai1) exhibit social deficits, increased seizure susceptibility, and altered brain development
The adhesion G protein-coupled receptor BAI1/ADGRB1 plays an important role in
suppressing angiogenesis, mediating phagocytosis, and acting as a brain tumor suppressor …
suppressing angiogenesis, mediating phagocytosis, and acting as a brain tumor suppressor …
GPR37L1 controls maturation and organization of cortical astrocytes during development
Astrocyte maturation is crucial to proper brain development and function. This maturation
process includes the ramification of astrocytic morphology and the establishment of …
process includes the ramification of astrocytic morphology and the establishment of …
Promoter DNA hypermethylation–implications for Alzheimer's disease
Recent methylome-wide association studies (MWAS) in humans have solidified the concept
that aberrant DNA methylation is associated with Alzheimer's disease (AD). We summarize …
that aberrant DNA methylation is associated with Alzheimer's disease (AD). We summarize …