100 years of Bacillus Calmette–Guérin immunotherapy: from cattle to COVID-19
Abstract Bacillus Calmette–Guérin (BCG) is the most widely used vaccine worldwide and
has been used to prevent tuberculosis for a century. BCG also stimulates an anti-tumour …
has been used to prevent tuberculosis for a century. BCG also stimulates an anti-tumour …
What have we learnt about BCG vaccination in the last 20 years?
HM Dockrell, SG Smith - Frontiers in immunology, 2017 - frontiersin.org
A number of new tuberculosis (TB) vaccines have been or are entering clinical trials, which
include genetically modified mycobacteria, mycobacterial antigens delivered by viral …
include genetically modified mycobacteria, mycobacterial antigens delivered by viral …
Tuberculosis vaccine: A journey from BCG to present
Tuberculosis (TB) is the leading cause of death worldwide due to an infectious disease,
causing around 1.6 million deaths each year. This situation has become more complicated …
causing around 1.6 million deaths each year. This situation has become more complicated …
The success and failure of BCG—implications for a novel tuberculosis vaccine
P Andersen, TM Doherty - Nature Reviews Microbiology, 2005 - nature.com
Over the past 50 years, the Mycobacterium bovis bacille Calmette–Guérin (BCG) vaccine
against tuberculosis (TB) has maintained its position as the world's most widely used …
against tuberculosis (TB) has maintained its position as the world's most widely used …
A Mycobacterium tuberculosis-specific subunit vaccine that provides synergistic immunity upon co-administration with Bacillus Calmette-Guérin
JS Woodworth, HS Clemmensen, H Battey… - Nature …, 2021 - nature.com
Given the encouraging clinical results of both candidate subunit vaccines and revaccination
with Bacillus Calmette-Guérin (BCG) against tuberculosis (TB), there is support for …
with Bacillus Calmette-Guérin (BCG) against tuberculosis (TB), there is support for …
Tuberculosis: what we don't know can, and does, hurt us
Mycobacterium tuberculosis has a penetrance of its host population that would be the envy
of most human pathogens. About one-third of the human population would have a positive …
of most human pathogens. About one-third of the human population would have a positive …
Deletion of RD1 from Mycobacterium tuberculosis Mimics Bacille Calmette-Guérin Attenuation
KN Lewis, R Liao, KM Guinn, MJ Hickey… - The Journal of …, 2003 - academic.oup.com
The tuberculosis (TB) vaccine bacille Calmette-Guérin (BCG) is a live attenuated organism,
but the mutation responsible for its attenuation has never been defined. Recent genetic …
but the mutation responsible for its attenuation has never been defined. Recent genetic …
Genome plasticity of BCG and impact on vaccine efficacy
To understand the evolution, attenuation, and variable protective efficacy of bacillus
Calmette–Guérin (BCG) vaccines, Mycobacterium bovis BCG Pasteur 1173P2 has been …
Calmette–Guérin (BCG) vaccines, Mycobacterium bovis BCG Pasteur 1173P2 has been …
Health impacts of environmental mycobacteria
TP Primm, CA Lucero… - Clinical microbiology …, 2004 - Am Soc Microbiol
Environmental mycobacteria are emerging pathogens causing opportunistic infections in
humans and animals. The health impacts of human-mycobacterial interactions are complex …
humans and animals. The health impacts of human-mycobacterial interactions are complex …
Key advances in vaccine development for tuberculosis—Success and challenges
Breakthrough findings in the clinical and preclinical development of tuberculosis (TB)
vaccines have galvanized the field and suggest, for the first time since the development of …
vaccines have galvanized the field and suggest, for the first time since the development of …