Single-particle cryo-electron microscopy (cryo-EM) is a technique that takes projection
images of biomolecules frozen at cryogenic temperatures. A major advantage of this …

Macromolecules change their shape (conformation) in the process of carrying out their
functions. The imaging by cryo-electron microscopy of rapidly-frozen, individual copies of …

Image processing in cryogenic electron tomography (cryoET) is currently at a similar state as
Single Particle Analysis (SPA) in cryogenic electron microscopy (cryoEM) was a few years …

This article presents an original approach for extracting atomic-resolution landscapes of
continuous conformational variability of biomolecular complexes from cryo electron …

Cryo electron tomography (cryo-ET) allows observing macromolecular complexes in their
native environment. The common routine of subtomogram averaging (STA) allows obtaining …

Cryo-electron microscopy (cryo-EM) has recently become a leading method for obtaining
high-resolution structures of biological macromolecules. However, cryo-EM is limited to …

ContinuousFlex is a user-friendly open-source software package for analyzing continuous
conformational variability of macromolecules in cryo electron microscopy (cryo-EM) and cryo …

The power of computer simulations, including machine‐learning, has become an
inseparable part of scientific analysis of biological data. This has significantly impacted the …

Resolving the structural variability of proteins is often key to understanding the structure–
function relationship of those macromolecular machines. Single particle analysis using …

Single-particle cryo-electron microscopy (cryo-EM SPA) has recently emerged as an
exceptionally well-suited technique for determining the structure of membrane proteins …