Scorpion envenomation and inflammation: Beyond neurotoxic effects

MB Reis, KF Zoccal, LG Gardinassi, LH Faccioli - Toxicon, 2019 - Elsevier
Scorpion envenomation results in a wide range of clinical manifestations that are mostly
attributed to the activation of the autonomic nervous system by venom toxins. In fact …

Serotherapy against Voltage-Gated Sodium Channel-Targeting α-Toxins from Androctonus Scorpion Venom

MF Martin-Eauclaire, S Adi-Bessalem… - Toxins, 2019 - mdpi.com
Because of their venom lethality towards mammals, scorpions of the Androctonus genus are
considered a critical threat to human health in North Africa. Several decades of exploration …

Involvement of toll-like receptor 4 in neutrophil-mediated inflammation, oxidative stress and tissue damage induced by scorpion venom

D Khemili, F Laraba-Djebari, D Hammoudi-Triki - Inflammation, 2020 - Springer
Systemic inflammatory response and generation of oxidative stress are known to contribute
to scorpion venom-induced tissue damage. TLR receptors might represent a link between …

Modulation of tissue inflammatory response by histamine receptors in scorpion envenomation pathogenesis: involvement of H4 receptor

A Lamraoui, S Adi-Bessalem, F Laraba-Djebari - Inflammation, 2014 - Springer
The inflammatory response caused by scorpion venoms is a key event in the pathogenesis
of scorpion envenomation. This response was assessed in the cardiac, pulmonary, and …

Immunopathologic effects of scorpion venom on hepato-renal tissues: Involvement of lipid derived inflammatory mediators

A Lamraoui, S Adi-Bessalem… - … and molecular pathology, 2015 - Elsevier
Scorpion venoms are known to cause different inflammatory disorders through complex
mechanisms in various tissues. In the study here, the involvement of phospholipase A 2 …

Effects of atropine and propranolol on lung inflammation in experimental envenomation: comparison of two buthidae venoms

H Saidi, S Adi-Bessalem, D Hammoudi-Triki… - Journal of venomous …, 2013 - SciELO Brasil
Background Previous works had shown that scorpion venom induced neurotransmitter
elevation and an inflammatory response associated with various anatomo-pathological …

TNF-alpha modulates adipose macrophage polarization to M1 phenotype in response to scorpion venom

A Ait-Lounis, F Laraba-Djebari - Inflammation research, 2015 - Springer
Objective We previously reported that Androctonus australis hector (Aah) venom and its
toxic fraction affect adipose tissue metabolism. However, the contribution of immune system …

[HTML][HTML] Serological, biochemical and enzymatic alterations in rodents after experimental envenomation with Hadruroides lunatus scorpion venom

F Costal-Oliveira, C Guerra-Duarte, KLP Castro… - Toxicon, 2015 - Elsevier
Abstract Toxic effects of Peruvian Hadruroides lunatus scorpion venom on different
biochemical and enzymatic parameters in blood serum of Wistar rats and Swiss mice were …

Effect of cytokine antibodies in the immunomodulation of inflammatory response and metabolic disorders induced by scorpion venom

Z Taibi-Djennah, F Laraba-Djebari - International immunopharmacology, 2015 - Elsevier
Androctonus australis hector (Aah) venom and its neurotoxins may affect the neuro-
endocrine immunological axis due to their binding to ionic channels of axonal membranes …

Venoms

C Teixeira, V Moreira… - … : From Molecular and …, 2017 - Wiley Online Library
Animal venoms are potent inducers of tissue damage and inflammation. Understanding the
mechanisms involved in venom‐induced inflammation has been useful not only to …