Clusterin (CLU) or APOJ is a multifunctional glycoprotein that has been implicated in several
physiological and pathological states, including Alzheimer's disease (AD). With a prominent …

In the search for new genes in Alzheimer's disease, classic linkage-based and candidate-
gene-based association studies have been supplanted by exome sequencing, genome …

Alzheimer's disease (AD) represents the main form of dementia, and is a major public health
problem. Despite intensive research efforts, current treatments have only marginal …

Genetic variation in clusterin gene, also known as apolipoprotein J, has been associated
with Alzheimer's disease (AD) through replicated genome-wide studies, and plasma …

Alzheimer's disease (AD) is a progressive neurodegenerative disease with phenotypic
changes closely associated with both genetic variants and imaging pathology. Brain …

Neuronal activity directly promotes the production and secretion of amyloid β (Aβ).
Interestingly, neuronal hyperactivity can be observed in presymptomatic stages of both …

Background. People with Alzheimer disease (AD) are capable of new learning when
cognitive support is provided, suggesting that there is plasticity even in a degenerating …

BACKGROUND: We examined the effect of the novel Alzheimer's disease (AD) risk variant
rs11136000 single nucleotide polymorphism in the clusterin gene (CLU) on longitudinal …

The C allele at the rs11136000 locus in the clusterin (CLU) gene is the third strongest known
genetic risk factor for late-onset Alzheimer's disease (LOAD). A recent genome-wide …

Firstly discovered in rete testis fluid, clusterin is a glycoprotein present in most of the other
biological fluids. Several isoforms of clusterin are encoded from a single gene located on …