Cells differentiate and progress through development guided by a dynamic chromatin
landscape that mediates gene expression programmes. During development, mammalian …

A remarkable epigenetic remodelling process occurs shortly after fertilization, which restores
totipotency to the zygote. This involves global DNA demethylation, chromatin remodelling …

Currently, stem cells are reported to be involved in tumor formation, drug resistance and
recurrence. Inhibiting the proliferation of tumor cells, promoting their senescence and …

Despite the success of animal cloning by somatic cell nuclear transfer (SCNT) in many
species, the method is limited by its low efficiency. After zygotic genome activation (ZGA) …

X-chromosome inactivation is established during early development. In mice, transcriptional
repression of the paternal X-chromosome (Xp) and enrichment in epigenetic marks such as …

Simple Summary Myostatin (MSTN) negatively regulates skeletal muscle growth. Although
the role of MSTN in muscle hypertrophy can be investigated in depth, studies of MSTN in …

The substantial epigenetic remodeling that occurs during early stages of mammalian
embryonic development likely contributes to reprogramming the parental genomes from a …

Simple Summary UTX/KDM6A is a histone H3K27 demethylase and plays an important role
in mammalian development and human diseases such as urothelial cancer. We identified a …

A major factor limiting the development of somatic cell nuclear transfer (SCNT) technology is
the low success rate of pregnancy, mainly due to placental abnormalities disrupting the …

Myostatin (Mstn) is an important growth/differentiation factor, and knockdown of Mstn
reduces fat content. Here, we knocked down Mstn expression in C2C12 myoblasts and then …