▪ Abstract Mechanical processes are involved in nearly every facet of the cell cycle.
Mechanical forces are generated in the cell during processes as diverse as chromosomal …

Single-molecule force experiments in vitro enable the characterization of the mechanical
response of biological matter at the nanometer scale. However, they do not reveal the …

Soluble N-ethylmaleimide–sensitive factor attachment protein receptor (SNARE) proteins
drive membrane fusion by assembling into a four-helix bundle in a zippering process. Here …

Mechanical forces exerted by laser tweezers or atomic force microscopes can be used to
drive rare transitions in single molecules, such as unfolding of a protein or dissociation of a …

Background—Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited
genetic myocardial disease characterized by fibrofatty replacement of the myocardium and a …

Cells can sense and transduce a broad range of mechanical forces into distinct sets of
biochemical signals that ultimately regulate cellular processes, including adhesion …

All-atom molecular dynamics simulations have become increasingly popular as a tool to
investigate protein function and dynamics. However, researchers are concerned about the …

The mechanical unfolding of the muscle protein titin by atomic force microscopy was a
landmark in our understanding of single-biomolecule mechanics. Molecular dynamics …

We can track the positions and movements of all the atoms in small proteins as they fold and
unfold by combining experimental studies with atomic-resolution molecular dynamics …

Proteins show diverse responses when placed under mechanical stress. The molecular
origins of their differing mechanical resistance are still unclear, although the orientation of …