Roles of the polybasic furin cleavage site of spike protein in SARS‐CoV‐2 replication, pathogenesis, and host immune responses and vaccination
MG Hossain, Y Tang, S Akter… - Journal of medical …, 2022 - Wiley Online Library
The polybasic furin cleavage site insertion with four amino acid motifs (PRRA) in spike
protein's S1/S2 junction site is important in determining viral infectivity, transmission, and …
protein's S1/S2 junction site is important in determining viral infectivity, transmission, and …
[HTML][HTML] Review of concerned SARS-CoV-2 variants like Alpha (B. 1.1. 7), Beta (B. 1.351), Gamma (P. 1), Delta (B. 1.617. 2), and Omicron (B. 1.1. 529), as well as …
The coronavirus known as COVID-19, which causes pandemics, is causing a global
epidemic at a critical stage today. Furthermore, novel mutations in the SARS-CoV-2 spike …
epidemic at a critical stage today. Furthermore, novel mutations in the SARS-CoV-2 spike …
[HTML][HTML] 新型冠状病毒Omicron 变异株研究进展
黄云， 李依红， 谢仕兰， 容祖华， 李柏生， 康敏… - 中华流行病学 …, 2022 - html.rhhz.net
新型冠状病毒Omicron (B. 1.1. 529) 变异株具有传播力强, 传播速度快, 免疫逃逸显著等特点,
给新型冠状病毒肺炎疫情防控带来新的挑战. 该变异株于2021 年11 月在南非被发现后, 历时2 …
给新型冠状病毒肺炎疫情防控带来新的挑战. 该变异株于2021 年11 月在南非被发现后, 历时2 …
Neutralization of SARS-CoV-2 variants of concern harboring Q677H
The sensitivity of SARS-CoV-2 variants of concern (VOCs) to neutralizing antibodies has
largely been studied in the context of key receptor binding domain (RBD) mutations …
largely been studied in the context of key receptor binding domain (RBD) mutations …
Novel small-molecule inhibitors of the SARS-CoV-2 spike protein binding to neuropilin 1
A Kolarič, M Jukič, U Bren - Pharmaceuticals, 2022 - mdpi.com
Furin cleavage of the SARS-CoV-2 spike protein results in a polybasic terminal sequence
termed the C-end rule (CendR), which is responsible for the binding to neuropilin 1 (NRP1) …
termed the C-end rule (CendR), which is responsible for the binding to neuropilin 1 (NRP1) …
O-linked sialoglycans modulate the proteolysis of SARS-CoV-2 spike and likely contribute to the mutational trajectory in variants of concern
E Gonzalez-Rodriguez, M Zol-Hanlon… - ACS central …, 2023 - ACS Publications
The emergence of a polybasic cleavage motif for the protease furin in SARS-CoV-2 spike
has been established as a major factor for human viral transmission. The region N-terminal …
has been established as a major factor for human viral transmission. The region N-terminal …
Potential COVID‐19 therapeutic approaches targeting angiotensin‐converting enzyme 2; an updated review
COVID‐19 has spread swiftly throughout the world posing a global health emergency. The
significant numbers of deaths attributed to this pandemic have researchers battling to …
significant numbers of deaths attributed to this pandemic have researchers battling to …
SARS-CoV-2 S mutations: a lesson from the viral world to understand how human furin works
L Cassari, A Pavan, G Zoia, M Chinellato… - International Journal of …, 2023 - mdpi.com
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the etiological agent
responsible for the worldwide pandemic and has now claimed millions of lives. The virus …
responsible for the worldwide pandemic and has now claimed millions of lives. The virus …
[HTML][HTML] Dynamics of SARS-CoV-2 variants of concern (VOC) in Bangladesh during the first half of 2021
Bangladesh is the second-worst-affected country in South Asia by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2). The aim of this study is to examine genome …
syndrome coronavirus 2 (SARS-CoV-2). The aim of this study is to examine genome …
Capturing a crucial 'disorder-to-order transition'at the heart of the coronavirus molecular pathology—triggered by highly persistent, interchangeable salt-bridges
The COVID-19 origin debate has greatly been influenced by genome comparison studies of
late, revealing the emergence of the Furin-like cleavage site at the S1/S2 junction of the …
late, revealing the emergence of the Furin-like cleavage site at the S1/S2 junction of the …