[PDF][PDF] Update 1 of: computational modeling approaches to structure–function analysis of G protein-coupled receptors
F Fanelli, PG De Benedetti - Chemical Reviews-Columbus, 2011 - researchgate.net
Any aspect of cell activity is regulated by extracellular signals that are recognized, decoded,
and transduced inside the cell via different classes of plasma membrane receptors. 1À3 G …
and transduced inside the cell via different classes of plasma membrane receptors. 1À3 G …
Detection and characterization of 3D-signature phosphorylation site motifs and their contribution towards improved phosphorylation site prediction in proteins
Background Phosphorylation of proteins plays a crucial role in the regulation and activation
of metabolic and signaling pathways and constitutes an important target for pharmaceutical …
of metabolic and signaling pathways and constitutes an important target for pharmaceutical …
Comparative genomics and functional annotation of bacterial transporters
MS Gelfand, DA Rodionov - Physics of Life Reviews, 2008 - Elsevier
Transport proteins are difficult to study experimentally, and because of that their functional
characterization trails that of enzymes. The comparative genomic analysis is a powerful …
characterization trails that of enzymes. The comparative genomic analysis is a powerful …
Developing a high-quality scoring function for membrane protein structures based on specific inter-residue interactions
Membrane proteins are of particular biological and pharmaceutical importance, and
computational modeling and structure prediction approaches play an important role in …
computational modeling and structure prediction approaches play an important role in …
Advances in the development and application of computational methodologies for structural modeling of G-protein-coupled receptors
JC Mobarec, M Filizola - Expert opinion on drug discovery, 2008 - Taylor & Francis
Background: Despite the large amount of experimental data accumulated in the past decade
on G-protein-coupled receptor (GPCR) structure and function, understanding of the …
on G-protein-coupled receptor (GPCR) structure and function, understanding of the …
Network pattern of residue packing in helical membrane proteins and its application in membrane protein structure prediction
De novo protein structure prediction plays an important role in studies of helical membrane
proteins as well as structure-based drug design efforts. Developing an accurate scoring …
proteins as well as structure-based drug design efforts. Developing an accurate scoring …
How strongly do sequence conservation patterns and empirical scales correlate with exposure patterns of transmembrane helices of membrane proteins?
Given the difficulty in determining high‐resolution structures of helical membrane proteins,
sequence‐based prediction methods can be useful in elucidating diverse physiological …
sequence‐based prediction methods can be useful in elucidating diverse physiological …
Conserved network properties of helical membrane protein structures and its implication for improving membrane protein homology modeling at the twilight zone
J Gao, Z Li - Journal of computer-aided molecular design, 2009 - Springer
Homology modeling techniques remain an important tool for membrane protein studies and
membrane protein-targeted drug development. Due to the paucity of available structure …
membrane protein-targeted drug development. Due to the paucity of available structure …
Method to assess packing quality of transmembrane α-helices in proteins. 1. Parametrization using structural data
AO Chugunov, VN Novoseletsky… - Journal of chemical …, 2007 - ACS Publications
Integral membrane proteins (MPs) are pharmaceutical targets of exceptional importance.
Modern methods of three-dimensional protein structure determination often fail to supply the …
Modern methods of three-dimensional protein structure determination often fail to supply the …
TMDIM: an improved algorithm for the structure prediction of transmembrane domains of bitopic dimers
Abstract α α-Helical transmembrane proteins are the most important drug targets in rational
drug development. However, solving the experimental structures of these proteins remains …
drug development. However, solving the experimental structures of these proteins remains …