Heterotrimeric G proteins are key players in transmembrane signaling by coupling a huge
variety of receptors to channel proteins, enzymes, and other effector molecules. Multiple …

The pancreatic islets are richly innervated by parasympathetic, sympathetic and sensory
nerves. Several different neurotransmitters are stored within the terminals of these nerves …

Acetylcholine (ACh), the major parasympathetic neurotransmitter, is released by
intrapancreatic nerve endings during the preabsorptive and absorptive phases of feeding. In …

Nitric oxide (NO) is a widespread, potent, biological mediator that has many physiological
and pathophysiological roles. Research in the field of NO appears to have followed a …

Members of the muscarinic acetylcholine receptor family (M1–M5) have central roles in the
regulation of many fundamental physiological functions,. Identifying the specific receptor …

Acetylcholine regulates hormone secretion from the pancreatic islet and is thus crucial for
glucose homeostasis. Little is known, however, about acetylcholine (cholinergic) signaling in …

Cholinergic agents elicit prominent smooth muscle contractions via stimulation of muscarinic
receptors that comprise five distinct subtypes (M1–M5). Although such contractions are …

Pancreatic muscarinic acetylcholine receptors play an important role in stimulating insulin
and glucagon secretion from islet cells. To study the potential role of the M3 muscarinic …

Alzheimer's disease (AD) is a neurodegenerative disorder and the major cause of dementia.
According to predictions of the World Health Organization, more than 150 million people …

Second generation antipsychotics (SGAs) are widely prescribed to treat various disorders,
most notably schizophrenia and bipolar disorder; however, SGAs can cause abnormal …